مورد إلكتروني
Association between circulating adipocytokine concentrations and microvascular complications in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of controlled cross-sectional studies.
| العنوان: | Association between circulating adipocytokine concentrations and microvascular complications in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of controlled cross-sectional studies. |
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| بيانات النشر: | Elsevier Inc. (E-mail: usjcs@elsevier.com) United States 2016-06-24 |
| تفاصيل مُضافة: | Paz-Filho G.J. Nunes V.D.S. Mastronardi C.A. Neeman T. Rodriguez A.J. |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background The adipocytokines leptin and adiponectin have been variously associated with diabetic microvascular complications. No comprehensive clinical data exist examining the association between adipocytokines and the presence of these complications. Methods This is a systematic review of cross-sectional studies comparing circulating adipocytokines in patients with type 2 diabetes mellitus (T2DM), with and without microvascular complications. Studies were retrieved from MEDLINE, EMBASE, Scopus and Cochrane databases. Study quality was evaluated using a modified Newcastle-Ottawa Scale. Meta-analysis was performed using an inverse-variance model, providing standardised mean differences (SMD) and 95% confidence intervals (CI). Heterogeneity was determined by I2 statistic. Results Amongst 554 identified studies, 28 were included in the review. Study quality range was 3.5-9 (maximum 11). Higher leptin levels were associated with microalbuminuria (SMD = 0.41; 95% CI = 0.14-0.67; n = 901; p = 0.0003), macroalbuminuria (SMD = 0.68; 95% CI = 0.30-1.06; n = 406; p = 0.0004), and neuropathy (SMD = 0.26; 95% CI = 0.07-0.44; n = 609; p = 0.008). Higher adiponectin levels were associated with microalbuminuria (SMD = 0.55; 95% CI = 0.29-0.81, n = 274; p < 0.001), macroalbuminuria (SMD = 1.37; 95% CI = 0.78-1.97, n = 246; p < 0.00001), neuropathy (SMD = 0.25; 95% CI = 0.14-0.36; n = 1516; p < 0.00001), and retinopathy (SMD = 0.38; 95% CI = 0.25-0.51; n = 1306; p < 0.00001). Meta-regression suggested no influence of body mass index and duration of diabetes on effect size, and a weak trend in terms of age on effect size. Discussion Our meta-analysis suggests leptin and adiponectin levels are higher in T2DM patients with microvascular complications. Studies were limited by cross-sectional design. Large prospective analyses are required to validate these findings.Copyright © 2016 The Authors. |
| مصطلحات الفهرس: | Medline, meta analysis, microalbuminuria, priority journal, proliferative diabetic retinopathy, protein blood level, quality control, rating scale, Scopus, sensitivity analysis, systematic review, trend study, vascular disease/co [Complication], adipocytokine/ec [Endogenous Compound], adiponectin/ec [Endogenous Compound], Newcastle-Ottawa scale, non insulin dependent diabetes mellitus, leptin/ec [Endogenous Compound], diabetic microvascular complication/co [Complication], article, body mass, Cochrane Library, confidence interval, cross-sectional study, diabetic nephropathy, diabetic neuropathy, diabetic patient, diabetic retinopathy, disease association, disease duration, effect size, Embase, human, macroalbuminuria, Article |
| URL: | Journal of Diabetes and its Complications LibKey Link |
| الإتاحة: | Open access content. Open access content Copyright 2016 Elsevier B.V., All rights reserved. |
| أرقام أخرى: | AUSHL oai:repository.monashhealth.org:1/40009 Journal of Diabetes and its Complications. 30 (2) (pp 357-367), 2016. Date of Publication: 01 Mar 2016. 1056-8727 https://repository.monashhealth.org/monashhealthjspui/handle/1/40009Test 607253996 (Rodriguez, Mastronardi, Paz-Filho) Department of Genome Sciences, John Curtin School of Medical Research, Australian National University, 131 Garran Rd, Acton, ACT 2601, Australia (Nunes) Department of Internal Medicine, Botucatu Medical School, State University, UNESP, Sao Paulo, Faculdade de Medicina, Distrito de Rubiao Junior s/n, Botucatu, SP CEP 18618-000, Brazil (Neeman) Statistical Consulting Unit, Australian National University, Canberra, John Dedman Mathematical Sciences Building, 27 Union Lane, Acton, ACT 2601, Australia (Rodriguez) Bone and Muscle Health Research Group, Department of Medicine, Monash University, Monash Medical Centre (Monash University), 246 Clayton Rd, Clayton, VIC 3168, Australia Mastronardi C.A.; claudio.mastronardi@anu.edu.au Paz-Filho G.J.; gilberto.pazfilho@anu.edu.au Nunes V.D.S.; vsnunes@fmb.unesp.br Neeman T.; teresa.neeman@anu.edu.au Rodriguez A.J.; alexander.rodriguez@monash.edu 1305118585 |
| المصدر المساهم: | MONASH HEALTH LIBRS From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1305118585 |
| قاعدة البيانات: | OAIster |
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