مورد إلكتروني
Long-Term Survival and Dialysis Dependency Following Acute Kidney Injury in Intensive Care: Extended Follow-up of a Randomized Controlled Trial.
| العنوان: | Long-Term Survival and Dialysis Dependency Following Acute Kidney Injury in Intensive Care: Extended Follow-up of a Randomized Controlled Trial. |
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| بيانات النشر: | Public Library of Science (E-mail: plos@plos.org) United States 2014-03-21 |
| تفاصيل مُضافة: | Bird S. Caf T. Weisbrodt L. Whereat S. Shehabi Y. Bass F. Edhouse P. Jenkins M. Jordon A. O'Connor A. Totaro R. Honeysett L. Inskip D. Sidoli R. Nair P. Reynolds C. Banerjee A. Kong J. Skelly C. Brown J. Gilder E. McArthur C. Newby L. Simmonds C. Henderson S. Mehrtens J. Sugden D. Kalkoff M. McGregor K. Shaw C. Morgan J. Gregory K. Sutton J. Garrett P. Buckley A. McDonald S. Joyce C. Harward M. Sexton G. Perkins K. Starr T. Flabouris A. O'Connor S. Rivett J. Turner A. McAllister R. Trubody V. Eastwood G. Peck L. Fletcher J. Ihle B. Ho S. Micallef J. Murray L. Botha J. Allsop S. Vuat J. Cattigan C. Elderkin T. Walker C. Galt P. Gillies A. Harley N. Barge D. Santamaria J. Holmes J. Smith R. Scheinkestel C. Donaldson H. Vallance S. French C. Bates S. Butler J. Breheny F. Palermo A. Dobb G. Chamberlain J. Lord P. Jun M. Yianni A. D'Haeseleer S. Lipman J. Dunlop R. Lassig-Smith M. Gallagher M. Cass A. Bellomo R. Finfer S. Gattas D. Lee J. Lo S. McGuinness S. Myburgh J. Parke R. Rajbhandari D. Mitchell I. Taylor E. Whyte R. Raza A. Nand K. Sara T. Millis D. Wong H. Harrigan P. Hardie M. Whitaker D. Bhonagiri D. Micallef S. Ellem K. Lintott M. Cole L. Cuzner C. |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background:The incidence of acute kidney injury (AKI) is increasing globally and it is much more common than end-stage kidney disease. AKI is associated with high mortality and cost of hospitalisation. Studies of treatments to reduce this high mortality have used differing renal replacement therapy (RRT) modalities and have not shown improvement in the short term. The reported long-term outcomes of AKI are variable and the effect of differing RRT modalities upon them is not clear. We used the prolonged follow-up of a large clinical trial to prospectively examine the long-term outcomes and effect of RRT dosing in patients with AKI.Methods and Findings:We extended the follow-up of participants in the Randomised Evaluation of Normal vs. Augmented Levels of RRT (RENAL) study from 90 days to 4 years after randomization. Primary and secondary outcomes were mortality and requirement for maintenance dialysis, respectively, assessed in 1,464 (97%) patients at a median of 43.9 months (interquartile range [IQR] 30.0-48.6 months) post randomization. A total of 468/743 (63%) and 444/721 (62%) patients died in the lower and higher intensity groups, respectively (risk ratio [RR] 1.04, 95% CI 0.96-1.12, p = 0.49). Amongst survivors to day 90, 21 of 411 (5.1%) and 23 of 399 (5.8%) in the respective groups were treated with maintenance dialysis (RR 1.12, 95% CI 0.63-2.00, p = 0.69). The prevalence of albuminuria among survivors was 40% and 44%, respectively (p = 0.48). Quality of life was not different between the two treatment groups. The generalizability of these findings to other populations with AKI requires further exploration. Conclusion(s):Patients with AKI requiring RRT in intensive care have high long-term mortality but few require maintenance dialysis. Long-term survivors have a heavy burden of proteinuria. Increased intensity of RRT does not reduce mortality or subsequent treatment with dialysis.Trial registration:http://www.ClinicalTrials.govTest NCT00221013 Please see later |
| مصطلحات الفهرس: | glomerulus filtration rate, acute kidney failure, adult, aged, APACHE, article, death, dialysis, diastolic blood pressure, female, follow up, human, incidence, intensive care, long term survival, macroalbuminuria, major clinical study, male, microalbuminuria, middle aged, mortality, outcome assessment, prevalence, prospective study, quality of life, randomized controlled trial, Article |
| URL: | PLoS Medicine Click here for full text options LibKey Link |
| الإتاحة: | Open access content. Open access content Copyright 2019 Elsevier B.V., All rights reserved. |
| أرقام أخرى: | AUSHL oai:repository.monashhealth.org:1/41615 PLoS Medicine. 11 (2) (no pagination), 2014. Article Number: e1001601. Date of Publication: 01 Feb 2014. 1549-1277 https://repository.monashhealth.org/monashhealthjspui/handle/1/41615Test 24523666 [http://www.ncbi.nlm.nih.gov/pubmed/?term=24523666Test] 372525541 (Gallagher, Cass, Finfer, Gattas, Lee, Lo, Myburgh, Rajbhandari) The George Institute for Global Health, Sydney, Australia (Gallagher, Finfer) University of Sydney, Sydney, Australia (Cass) Menzies School of Health Research, Darwin, Australia (Bellomo) Austin Hospital, Heidelberg, Australia (Gattas) Royal Prince Alfred Hospital, Camperdown, Australia (McGuinness, Parke) Auckland City Hospital, Auckland, New Zealand (Myburgh) St. George Clinical School, University of New South Wales, Sydney, Australia (Mitchell, Taylor, Whyte) The Canberra Hospital, Australian Capital Territory, Australia (Raza, Nand, Sara) Blacktown Hospital, New South Wales, Australia (Millis, Wong) Concord Hospital, New South Wales, Australia (Harrigan, Hardie, Whitaker) John Hunter Hospital, New South Wales, Australia (Bhonagiri, Micallef) Liverpool Hospital, New South Wales, Australia (Ellem, Lintott) Mater Calvary Hospital, Newcastle, NSW, Australia (Cole, Cuzner, Weisbrodt, Whereat) Nepean Hospital, New South Wales, Australia (Shehabi, Bass, Edhouse, Jenkins) Prince of Wales Hospital, New South Wales, Australia (Finfer, Bird, O'Connor) Royal North Shore Hospital, New South Wales, Australia (Rajbhandari, Totaro, Honeysett) Royal Prince Alfred Hospital, New South Wales, Australia (Myburgh, Inskip, Sidoli) St George Hospital, New South Wales, Australia (Nair, Reynolds) St Vincent's Hospital, New South Wales, Australia (Banerjee, Kong, Skelly) Westmead Hospital, New South Wales, Australia (McGuinness, Parke, Brown, Gilder) Auckland City Hospital/CVICU, New Zealand (McArthur, Newby, Simmonds) Auckland City Hospital/DCCM, New Zealand (Henderson, Mehrtens, Sugden) Christchurch Hospital, New Zealand (Kalkoff, McGregor, Shaw) Whangarei Hospital, New Zealand (Morgan, Gregory, Sutton) Mater Adult and Mater Private Hospital, Queensland, Australia (Garrett, Buckley, McDonald) Nambour General Hospital, Queensland, Australia (Joyce, Harward, Sexton, Perkins) Princess Alexandra Hospital, Queensland, Australia Gallagher M.; mgallagher@georgeinstitute.org.au 1305113102 |
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| رقم الانضمام: | edsoai.on1305113102 |
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