مورد إلكتروني
Seroresponses and safety of 13-valent pneumococcal conjugate vaccination in kidney transplant recipients.
| العنوان: | Seroresponses and safety of 13-valent pneumococcal conjugate vaccination in kidney transplant recipients. |
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| بيانات النشر: | Blackwell Publishing Inc. (E-mail: subscrip@blackwellpub.com) United States 2018-04-18 |
| تفاصيل مُضافة: | Dendle C. Stuart R.L. Polkinghorne K.R. Balloch A. Kanellis J. Ling J. Kummrow M. Moore C. Thursky K. Buttery J. Mulholland K. Gan P.-Y. Holdsworth S. Mulley W.R. |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background: Conjugated pneumococcal vaccine is recommended for kidney transplant recipients, however, their immunogenicity and potential to trigger allograft rejection though generation of de novo anti-human leukocyte antigen antibodies has not been well studied. Method(s): Clinically stable kidney transplant recipients participated in a prospective cohort study and received a single dose of 13-valent conjugate pneumococcal vaccine. Anti-pneumococcal IgG was measured for the 13 vaccine serotypes pre and post vaccination and functional anti-pneumococcal IgG for 4 serotypes post vaccination. Anti-human leukocyte antigen antibodies antibodies were measured before and after vaccination. Kidney transplant recipients were followed clinically for 12 months for episodes of allograft rejection or invasive pneumococcal disease. Result(s): Forty-five kidney transplant recipients participated. Median days between pre and post vaccination serology was 27 (range 21-59). Post vaccination, there was a median 1.1 to 1.7-fold increase in anti-pneumococcal IgG antibody concentrations for all 13 serotypes. Kidney transplant recipients displayed a functional antibody titer >=1:8 for a median of 3 of the 4 serotypes. Post vaccination, there were no de novo anti-human leukocyte antigen antibodies, no episodes of biopsy proven rejection or invasive pneumococcal disease. Conclusion(s): A single dose of 13-valent conjugate pneumococcal vaccine elicits increased titers and breadth of functional anti-pneumococcal antibodies in kidney transplant recipients without stimulating rejection or donor-specific antibodies.Copyright © 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd |
| مصطلحات الفهرس: | human, adult, antibody blood level, antibody detection, antibody response, antibody titer, antigen antibody complex, arthralgia/si [Side Effect], article, clinical article, cohort analysis, female, graft recipient, kidney graft, male, patient safety, priority journal, prospective study, seroconversion, serotype, single drug dose, treatment response, vaccination, HLA antibody/ec [Endogenous Compound], immunoglobulin G antibody/ec [Endogenous Compound], Pneumococcus vaccine/ae [Adverse Drug Reaction], Pneumococcus vaccine/im [Intramuscular Drug Administration], Article |
| URL: | Transplant Infectious Disease Click here for full text options LibKey Link |
| الإتاحة: | Open access content. Open access content Copyright 2018 Elsevier B.V., All rights reserved. |
| أرقام أخرى: | AUSHL oai:repository.monashhealth.org:1/37505 Transplant Infectious Disease. 20 (2) (no pagination), 2018. Article Number: e12866. Date of Publication: April 2018. 1398-2273 https://repository.monashhealth.org/monashhealthjspui/handle/1/37505Test Dendle, Claire; ORCID: http://orcid.org/0000-0002-6642-5365Test 29512234 [http://www.ncbi.nlm.nih.gov/pubmed/?term=29512234Test] 621509941 (Dendle, Stuart) Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University and Monash Infectious Diseases, Monash Health, Clayton, VIC, Australia (Polkinghorne, Kanellis, Gan, Holdsworth, Mulley) Centre for Inflammatory Diseases, School of Clinical Sciences, Monash University, Clayton, VIC, Australia (Polkinghorne, Kanellis, Ling, Holdsworth, Mulley) Department of Nephrology, Monash Medical Centre, Clayton, VIC, Australia (Polkinghorne, Buttery) Department of Epidemiology and Preventive Medicine, Monash University, Prahran, VIC, Australia (Balloch, Mulholland) Murdoch Children's Research Institute, Parkville, VIC, Australia (Kummrow, Moore) Victorian Transplantation and Immunogenetics Service, West Melbourne, VIC, Australia (Thursky) University of Melbourne, Parkville, VIC, Australia (Thursky) Victorian Infectious Diseases Service, Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia (Buttery) Department of Infection and Immunity, Monash Children's Hospital, Monash Health, Melbourne, VIC, Australia Dendle C.; claire.dendle@monash.edu 1305110014 |
| المصدر المساهم: | MONASH HEALTH LIBRS From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1305110014 |
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