مورد إلكتروني
Routine blood investigations have limited utility in surveillance of aggressive lymphoma in asymptomatic patients in complete remission.
| العنوان: | Routine blood investigations have limited utility in surveillance of aggressive lymphoma in asymptomatic patients in complete remission. |
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| بيانات النشر: | Nature Publishing Group (Houndmills, Basingstoke, Hampshire RG21 6XS, United Kingdom) United Kingdom 2018-10-12 |
| تفاصيل مُضافة: | Estacio O. Gilbertson M. Loh Z. Chong G. Grigg A. Ha F.J. Hawkes E.A. |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background: Patients with aggressive lymphoma achieving complete remission (CR) after first-line combination chemotherapy undergo regular surveillance to detect relapse. Current international guidelines recommend routine follow-up blood tests in this context, but evidence supporting this practice is limited. Method(s): We conducted a multi-centre retrospective analysis of all patients diagnosed with aggressive lymphoma treated with curative-intent chemotherapy who achieved CR for at least 3 months between 2000 and 2015. An abnormal blood test was defined as any new and unexplained abnormality for full blood examination, lactate dehydrogenase or erythrocyte sedimentation rate. Result(s): Three hundred and forty-six patients attended a total of 3084 outpatient visits; blood tests were performed at 90% of these appointments. Fifty-six (16%) patients relapsed. Routine laboratory testing detected relapse in only three patients (5% of relapses); in the remaining patients, relapse was suspected clinically (80%) or detected by imaging (15%). The sensitivity of all blood tests was 42% and the positive predictive value was 9%. No significant difference in survival was shown in patients who underwent a routine blood test within 3 months prior to relapse versus those who did not (p = 0.88). Conclusion(s): Routine blood tests demonstrate unacceptably poor performance characteristics, have no impact on survival and thus have limited value in the detection of relapse in routine surveillance.Copyright © 2018, Cancer Research UK. |
| مصطلحات الفهرس: | human tissue, adolescent, adult, aged, article, asymptomatic disease/di [Diagnosis], asymptomatic disease/dt [Drug Therapy], blood examination, cancer chemotherapy, cancer patient, cancer recurrence, controlled study, disease surveillance, erythrocyte sedimentation rate, female, human, intention to treat analysis, lactate dehydrogenase blood level, lymphoma/di [Diagnosis], lymphoma/dt [Drug Therapy], major clinical study, male, medical examination, multicenter study, outpatient care, predictive value, priority journal, relapse/di [Diagnosis], retrospective study, sensitivity and specificity, tumor regression, very elderly, antineoplastic agent/dt [Drug Therapy], lactate dehydrogenase/ec [Endogenous Compound], Article |
| URL: | British Journal of Cancer Click here for full text options LibKey Link |
| الإتاحة: | Open access content. Open access content Copyright 2019 Elsevier B.V., All rights reserved. |
| أرقام أخرى: | AUSHL oai:repository.monashhealth.org:1/36887 British Journal of Cancer. 119 (5) (pp 546-550), 2018. Date of Publication: 28 Aug 2018. 0007-0920 https://repository.monashhealth.org/monashhealthjspui/handle/1/36887Test 30033446 [http://www.ncbi.nlm.nih.gov/pubmed/?term=30033446Test] 623202309 (Hawkes, Loh, Chong, Grigg) Department of Oncology and Clinical Haematology, Austin Hospital, Heidelberg, VIC, Australia (Hawkes, Chong, Grigg) Olivia Newton-John Cancer Wellness and Research Centre, Austin Hospital, Heidelberg, VIC, Australia (Hawkes) Eastern Health, Box Hill, VIC, Australia (Loh, Estacio, Grigg) University of Melbourne, Parkville, VIC, Australia (Ha) Monash University, Clayton, VIC, Australia (Gilbertson) Department of Haematology, Monash Medical Center, Monash Health, Clayton, VIC, Australia Hawkes E.A.; eliza.hawkes@onjcri.org.au 1305109180 |
| المصدر المساهم: | MONASH HEALTH LIBRS From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1305109180 |
| قاعدة البيانات: | OAIster |
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