مورد إلكتروني

Positive fibroblast growth factor receptor 3 immunoreactivity is associated with low-grade non-invasive urothelial bladder cancer

التفاصيل البيبلوغرافية
العنوان: Positive fibroblast growth factor receptor 3 immunoreactivity is associated with low-grade non-invasive urothelial bladder cancer
بيانات النشر: 2015-01-01
تفاصيل مُضافة: Poyet, C. (Cédric)
Hermanns, T. (Thomas)
Zhong, Q. (Qing)
Drescher, E. (Eva)
Eberli, D. (Daniel)
Burger, M. (Maximilian)
Hofstaedter, F. (Ferdinand)
Hartmann, A. (Arndt)
Stöhr, R. (Robert)
Zwarthoff, E.C. (Ellen)
Sulser, T. (Tullio)
Wild, P.J. (Peter J.)
نوع الوثيقة: Electronic Resource
مستخلص: In addition to conventional clinicopathological parameters, molecular markers are also required in order to predict the course of disease in patients with urothelial bladder cancer (BC). Little is known about fibroblast growth factor receptor 3 (FGFR3) immunoreactivity and the clinical significance it may possess with regard to BC. The present study aimed to investigate the immunoreactivity of FGFR3 in primary urothelial bladder tumours, with regard to clinicopathological features and FGFR3 mutation status. Tissue microarrays were used to immunohistochemically analyse FGFR3 expression in 255 primary, unselected patients with BC. FGFR3 mutations were detected using SNaPshot analysis. Positive FGFR3 immunoreactivity was identified in 113/207 analysable cases (54.6%), and was significantly associated with FGFR3 mutation (P<0.001), low tumour stage (P<0.001), low histological grade (P<0.001) and a papillary growth pattern (P<0.001). Positive FGFR3 immunostaining (P=0.002) and FGFR3 mutation (P=0.002) were found to be significantly associated with increased disease-specific survival following univariate analysis, demonstrating a median follow-up period of 75 months. Using multivariate analyses, FGFR3 immunoreactivity was found not to be independent of classical pathological parameters. Immunohistochemical expression of FGFR3 is an early occurrence during the carcinogenesis of papillary non-invasive BC. The presence of FGFR3 immunoreactivity in non‑invasive papillary urothelial carcinomas may be utilised as an indicator of tumours possessing low-grade features and good prognosis.
مصطلحات الفهرس: Fibroblast growth factor receptor 3 protein, Grading, Molecular markers, Prognosis, Urothelial cancer, info:eu-repo/semantics/article
DOI: 10.3892.ol.2015.3691
URL: http://repub.eur.nl/pub/81354Test
الإتاحة: Open access content. Open access content
info:eu-repo/semantics/openAccess
ملاحظة: Oncology Letters vol. 10 no. 5, pp. 2753-2760
English
أرقام أخرى: QGQ oai:repub.eur.nl:81354
doi:10.3892/ol.2015.3691
urn:hdl:1765/81354
1295350894
المصدر المساهم: ERASMUS UNIVERSITEIT ROTTERDAM
From OAIster®, provided by the OCLC Cooperative.
رقم الانضمام: edsoai.on1295350894
قاعدة البيانات: OAIster