مورد إلكتروني
Transcranial Magnetic Stimulation Exerts “Rejuvenation” Effects on Corticostriatal Synapses after Partial Dopamine Depletion
| العنوان: | Transcranial Magnetic Stimulation Exerts “Rejuvenation” Effects on Corticostriatal Synapses after Partial Dopamine Depletion |
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| بيانات النشر: | John Wiley and Sons Inc 2021 |
| تفاصيل مُضافة: | Natale, G. Pignataro, A. Marino, G. Campanelli, Federica Calabrese, V. Cardinale, A. Pelucchi, S. Marcello, E. Gardoni, F. Viscomi, Maria Teresa Picconi, B. Ammassari-Teule, M. Calabresi, Paolo Ghiglieri, V. Campanelli F. (ORCID:0000-0002-6731-7067) Viscomi M. T. (ORCID:0000-0002-9096-4967) Calabresi P. (ORCID:0000-0003-0326-5509) |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Background: In experimental models of Parkinson's disease (PD), different degrees of degeneration to the nigrostriatal pathway produce distinct profiles of synaptic alterations that depend on progressive changes in N-methyl-D-aspartate receptors (NMDAR)-mediated functions. Repetitive transcranial magnetic stimulation (rTMS) induces modifications in glutamatergic and dopaminergic systems, suggesting that it may have an impact on glutamatergic synapses modulated by dopamine neurotransmission. However, no studies have so far explored the mechanisms of rTMS effects at early stages of PD. Objectives: We tested the hypothesis that in vivo application of rTMS with intermittent theta-burst stimulation (iTBS) pattern alleviates corticostriatal dysfunctions by modulating NMDAR-dependent plasticity in a rat model of early parkinsonism. Methods: Dorsolateral striatal spiny projection neurons (SPNs) activity was studied through ex vivo whole-cell patch-clamp recordings in corticostriatal slices obtained from 6-hydroxydopamine-lesioned rats, subjected to a single session (acute) of iTBS and tested for forelimb akinesia with the stepping test. Immunohistochemical analyses were performed to analyze morphological correlates of plasticity in SPNs. Results: Acute iTBS ameliorated limb akinesia and rescued corticostriatal long-term potentiation (LTP) in SPNs of partially lesioned rats. This effect was abolished by applying a selective inhibitor of GluN2B-subunit-containing NMDAR, suggesting that iTBS treatment could be associated with an enhanced activation of specific NMDAR subunits, which are major regulators of structural plasticity during synapse development. Morphological analyses of SPNs revealed that iTBS treatment reverted dendritic spine loss inducing a prevalence of thin-elongated spines in the biocytin-filled SPNs. Conclusions: Taken together, our data identify that an acute iTBS treatment produces a series of plastic changes underlying striatal compensatory adaptation in th |
| مصطلحات الفهرس: | dendritic spines, GluN2B, noninvasive brain stimulation, partial dopamine denervation, striatum, Animals, Corpus Striatum, Neuronal Plasticity, Rats, Synapses, Dopamine, Transcranial Magnetic Stimulation, Settore BIO/17 - ISTOLOGIA, info:eu-repo/semantics/article |
| URL: | info:eu-repo/semantics/altIdentifier/pmid/34339069 info:eu-repo/semantics/altIdentifier/wos/WOS:000680070300001 volume:36 issue:10 firstpage:2254 lastpage:2263 numberofpages:10 issueyear:2021 journal:MOVEMENT DISORDERS |
| الإتاحة: | Open access content. Open access content |
| ملاحظة: | English |
| أرقام أخرى: | SYC oai:publicatt.unicatt.it:10807/187381 10.1002/mds.28671 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85111833132 1289307382 |
| المصدر المساهم: | UNIV CATTOLICA DEL SACRO CUORE From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1289307382 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |