مورد إلكتروني
Lactate dehydrogenase activity drives hair follicle stem cell activation.
| العنوان: | Lactate dehydrogenase activity drives hair follicle stem cell activation. |
|---|---|
| المؤلفون: | Flores, Aimee |
| المصدر: | Nature cell biology; vol 19, iss 9, 1017-1026; 1465-7392 |
| بيانات النشر: | eScholarship, University of California 2017-09-01 |
| تفاصيل مُضافة: | Flores, Aimee Schell, John Krall, Abigail S Jelinek, David Miranda, Matilde Grigorian, Melina Braas, Daniel White, Andrew C Zhou, Jessica L Graham, Nicholas A Graeber, Thomas Seth, Pankaj Evseenko, Denis Coller, Hilary A Rutter, Jared Christofk, Heather R Lowry, William E |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Although normally dormant, hair follicle stem cells (HFSCs) quickly become activated to divide during a new hair cycle. The quiescence of HFSCs is known to be regulated by a number of intrinsic and extrinsic mechanisms. Here we provide several lines of evidence to demonstrate that HFSCs utilize glycolytic metabolism and produce significantly more lactate than other cells in the epidermis. Furthermore, lactate generation appears to be critical for the activation of HFSCs as deletion of lactate dehydrogenase (Ldha) prevented their activation. Conversely, genetically promoting lactate production in HFSCs through mitochondrial pyruvate carrier 1 (Mpc1) deletion accelerated their activation and the hair cycle. Finally, we identify small molecules that increase lactate production by stimulating Myc levels or inhibiting Mpc1 carrier activity and can topically induce the hair cycle. These data suggest that HFSCs maintain a metabolic state that allows them to remain dormant and yet quickly respond to appropriate proliferative stimuli. |
| مصطلحات الفهرس: | Hair Follicle, Stem Cells, Animals, Mice, Inbred C57BL, Knockout, Acrylates, Lactic Acid, Isoenzymes, L-Lactate Dehydrogenase, Anion Transport Proteins, Monocarboxylic Acid Transporters, Proto-Oncogene Proteins c-myc, Mitochondrial Membrane Transport Proteins, Signal Transduction, Cell Proliferation, Glycolysis, Genotype, Phenotype, Time Factors, Female, Male, Cellular Senescence, Lactate Dehydrogenase 5, Developmental Biology, Biological Sciences, Medical and Health Sciences, article |
| URL: | |
| الإتاحة: | Open access content. Open access content public |
| ملاحظة: | application/pdf Nature cell biology vol 19, iss 9, 1017-1026 1465-7392 |
| أرقام أخرى: | CDLER oai:escholarship.org:ark:/13030/qt1q76t50g qt1q76t50g https://escholarship.org/uc/item/1q76t50gTest https://escholarship.orgTest/ 1287335362 |
| المصدر المساهم: | UC MASS DIGITIZATION From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1287335362 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |