مورد إلكتروني
Quality of benzathine penicillin G: A multinational cross-sectional study
العنوان: | Quality of benzathine penicillin G: A multinational cross-sectional study |
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بيانات النشر: | JOHN WILEY & SONS LTD 2020 |
تفاصيل مُضافة: | Hand, R.M. Senarathna, Ganga Page-Sharp, Madhu Gray, K. Sika-Paotonu, D. Sheel, M. Chuang, Victor Martinez, Jorge Luna, Giuseppe Manning, L. Wyber, R. Carapetis, J.R. Batty, Kevin |
نوع الوثيقة: | Electronic Resource |
مستخلص: | Benzathine penicillin G (BPG) is used as first-line treatment for most forms of syphilis and as secondary prophylaxis against rheumatic heart disease (RHD). Perceptions that poor quality of BPG is linked to reported adverse effects and therapeutic failure may impact syphilis and RHD control programs. Clinical networks and web-based advertising were used to obtain vials of BPG from a wide range of countries. The quality of BPG was assessed using a high performance liquid chromatography assay capable of detecting relevant impurities and degradation products. Tests for water content, presence of heavy metals and physical characteristics of BPG, including particle size analysis and optical microscopy, also were conducted. Thirty-five batches of BPG were sourced from 16 countries across 4 WHO regions. All batches passed the US Pharmacopeia requirements for BPG injection (content), with no evidence of breakdown products or other detected contaminants. Water content and heavy metal analysis (n = 11) indicated adherence to regulatory standards and Good Manufacturing Practice. Particle size analysis (n = 20) found two batches with aggregated particles (>400 µm) that were dispersed following sonication. Current batches of BPG were of satisfactory pharmaceutical quality but aggregated particles were found in a modest proportion of samples. Future studies should focus on the physical characteristics of BPG which may contribute to variations in plasma penicillin concentrations an observed needle blockages in clinical practice. Pharmacopeial monographs could be revised to include standards on particle size and crystal morphology of BPG. |
مصطلحات الفهرس: | Science & Technology, Life Sciences & Biomedicine, Pharmacology & Pharmacy, benzathine benzylpenicillin, benzathine penicillin G, particle size analysis, pharmaceutical quality, RHEUMATIC-FEVER, SYPHILIS, Journal Article |
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الإتاحة: | Open access content. Open access content http://creativecommons.org/licenses/by/4.0Test |
أرقام أخرى: | LC0 oai:espace.curtin.edu.au:20.500.11937/85227 Hand, R.M. and Senarathna, S.M.D.K.G. and Page-Sharp, M. and Gray, K. and Sika-Paotonu, D. and Sheel, M. and Chuang, V.T.G. et al. 2020. Quality of benzathine penicillin G: A multinational cross-sectional study. Pharmacology Research and Perspectives. 8 (6): Article No. e00668. 10.1002/prp2.668 1281776205 |
المصدر المساهم: | CURTIN UNIV OF TECH From OAIster®, provided by the OCLC Cooperative. |
رقم الانضمام: | edsoai.on1281776205 |
قاعدة البيانات: | OAIster |
الوصف غير متاح. |