مورد إلكتروني
Clinical manifestations and management of patients with autoimmune polyendocrine syndrome type I
العنوان: | Clinical manifestations and management of patients with autoimmune polyendocrine syndrome type I |
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بيانات النشر: | Institutionen för medicinska vetenskaper 2009 |
تفاصيل مُضافة: | Husebye, Eystein S. Perheentupa, J. Rautemaa, R. Kämpe, Olle |
نوع الوثيقة: | Electronic Resource |
مستخلص: | Autoimmune polyendocrine syndrome type I (APS-I) is a monogenic model disease of autoimmunity. Its hallmarks are chronic mucocutaneous candidosis, hypoparathyroidism and adrenal insufficiency, but many other autoimmune disease components occur less frequently. The first components usually appear in childhood, but may be delayed to adolescence or early adult life. There is enormous variation in presentation and phenotype, which makes the diagnosis difficult. Antibodies against interferon-omega and -alpha have recently been shown to be sensitive and relatively specific markers for APS-I, and mutational analysis of the autoimmune regulator gene gives the diagnosis in >95% of cases. The treatment and follow-up of patients is demanding and requires the collaboration of specialists of several fields. However, the literature is especially sparse regarding information on treatment and follow-up; hence, we present here a comprehensive overview on clinical characteristics, treatment and follow-up based on personal experience and published studies. |
مصطلحات الفهرس: | Addison's disease, APECED, APS-1, APS-I, autoantibodies, autoimmune, autoimmune regulator, candidosis, hypoparathyroidism, polyglandular, Medical and Health Sciences, Medicin och hälsovetenskap, Article in journal, info:eu-repo/semantics/article, text |
DOI: | 10.1111.j.1365-2796.2009.02090.x |
URL: | Journal of Internal Medicine, 0954-6820, 2009, 265:5, s. 514-529 |
الإتاحة: | Open access content. Open access content info:eu-repo/semantics/restrictedAccess |
ملاحظة: | English |
أرقام أخرى: | UPE oai:DiVA.org:uu-106862 0000-0001-6091-9914 doi:10.1111/j.1365-2796.2009.02090.x PMID 19382991 ISI:000264959000002 1235298471 |
المصدر المساهم: | UPPSALA UNIV LIBR From OAIster®, provided by the OCLC Cooperative. |
رقم الانضمام: | edsoai.on1235298471 |
قاعدة البيانات: | OAIster |
DOI: | 10.1111.j.1365-2796.2009.02090.x |
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