مورد إلكتروني
FOXP3+ regulatory T cells in normal prostate tissue, postatrophic hyperplasia, prostatic intraepithelial neoplasia, and tumor histological lesions in men with and without prostate cancer
| العنوان: | FOXP3+ regulatory T cells in normal prostate tissue, postatrophic hyperplasia, prostatic intraepithelial neoplasia, and tumor histological lesions in men with and without prostate cancer |
|---|---|
| بيانات النشر: | Örebro universitet, Institutionen för medicinska vetenskaper Region Örebro län Department of Urology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden Department of Urology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden Department of Laboratory Medicine, Pathology, University Hospital Örebro, Örebro, Sweden Department of Urology, Örebro University Hospital, Örebro, Sweden Department of Urology, Örebro University Hospital, Örebro, Sweden Department of Hematology-Oncology, Molecular Pathology Laboratory, Addarii Institute of Oncology, University of Bologna, Bologna, Italy Department of Epidemiology, Boston University School of Public Health, Boston MA, USA Department of Hematology-Oncology, Molecular Pathology Laboratory, Addarii Institute of Oncology, University of Bologna, Bologna, Italy Hoboken, USA 2018 |
| تفاصيل مُضافة: | Davidsson, Sabina Andrén, Ove Ohlson, Anna-Lena Carlsson, Jessica Andersson, Swen-Olof Giunchi, Francesca Rider, Jennifer R. Fiorentino, Michelangelo |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | BACKGROUND: The tumor promoting or counteracting effects of the immune response to cancer development are thought to be mediated to some extent by the infiltration of regulatory T cells (Tregs ). In the present study we evaluated the prevalence of Treg populations in stromal and epithelial compartments of normal, post atrophic hyperplasia (PAH), prostatic intraepithelial neoplasia (PIN), and tumor lesions in men with and without prostate cancer. METHODS: Study subjects were 102 men consecutively diagnosed with localized prostate cancer undergoing radical prostatectomy and 38 men diagnosed with bladder cancer undergoing cystoprostatectomy without prostate cancer at the pathological examination. Whole mount sections from all patients were evaluated for the epithelial and stromal expression of CD4+ Tregs and CD8+ Tregs in normal, PAH, PIN, and tumor lesions. A Friedmańs test was used to investigate differences in the mean number of Tregs across histological lesions. Logistic regression was used to estimate crude and adjusted odds ratios (OR) for prostate cancer for each histological area. RESULTS: In men with prostate cancer, similarly high numbers of stromal CD4+ Tregs were identified in PAH and tumor, but CD4+ Tregs were less common in PIN. Greater numbers of epithelial CD4+ Tregs in normal prostatic tissue were positively associated with both Gleason score and pT-stage. We observed a fourfold increased risk of prostate cancer in men with epithelial CD4+ Tregs in the normal prostatic tissue counterpart. CONCLUSIONS: Our results may suggest a possible pathway through which PAH develops directly into prostate cancer in the presence of CD4+ Tregs and indicate that transformation of the anti-tumor immune response may be initiated even before the primary tumor is established. Funding Agencies:Foundation for Medical Research at Örebro University Hospital Lions Cancer Foundation Örebro County Council Research Committee |
| مصطلحات الفهرس: | CD4+FOXP3+ Tregs, Lag-3+ Tregs, prostate carcinoma, Endocrinology and Diabetes, Endokrinologi och diabetes, Urology and Nephrology, Urologi och njurmedicin, Article in journal, info:eu-repo/semantics/article, text |
| DOI: | 10.1002.pros.23442 |
| URL: | The Prostate, 0270-4137, 2018, 78:1, s. 40-47 |
| الإتاحة: | Open access content. Open access content info:eu-repo/semantics/restrictedAccess |
| ملاحظة: | English |
| أرقام أخرى: | UPE oai:DiVA.org:oru-63016 0000-0001-5533-7899 doi:10.1002/pros.23442 PMID 29105795 ISI:000417131400006 Scopus 2-s2.0-85037338544 1234107060 |
| المصدر المساهم: | UPPSALA UNIV LIBR From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.on1234107060 |
| قاعدة البيانات: | OAIster |
| DOI: | 10.1002.pros.23442 |
|---|