مورد إلكتروني
أعرض في EDS

The influences of indoor environmental factors and CD14 polymorphisms on asthma phenotypes in Chinese children.

التفاصيل البيبلوغرافية
العنوان: The influences of indoor environmental factors and CD14 polymorphisms on asthma phenotypes in Chinese children.
بيانات النشر: 2007
تفاصيل مُضافة: Wong, Yun Sze.
Chinese University of Hong Kong Graduate School. Division of Medical Sciences.
نوع الوثيقة: Electronic Resource
مستخلص: Wong, Yun Sze.
Thesis (M.Phil.)--Chinese University of Hong Kong, 2007.
Includes bibliographical references (leaves 142-162).
s in English and Chinese.
(in English) --- p.ii
(in Chinese) --- p.vi
Acknowledgement --- p.ix
Statement of Work --- p.x
Table of Contents --- p.xi
List of Tables --- p.xiv
List of Figures --- p.xvi
Glossary of Terms and Abbreviations --- p.xviii
Chapter Section I: --- Introduction --- p.1
Chapter Chapter 1: --- General Overview of Asthma --- p.2
Chapter 1.1 --- Asthma definition and its phenotype --- p.2
Chapter 1.2 --- Asthma epidemiology and its prevalence in past decades --- p.4
Chapter 1.3 --- Hygiene hypothesis and asthma development --- p.8
Chapter 1.4 --- Asthma pathogenesis and innate immunity --- p.12
Chapter 1.5 --- The environmental factors and genetic makeup in relation with asthma --- p.17
Chapter Chapter 2: --- Study Plan and Obj ective --- p.21
Chapter Section II: --- Literature Review --- p.24
Chapter Chapter 3: --- Indoor Environmental factors of Asthma --- p.25
Chapter 3.1 --- Overview of the indoor environmental factors --- p.25
Chapter 3.2 --- House dust endotoxin --- p.27
Chapter 3.2.1 --- Determinants of endotoxin exposure in home environment --- p.21
Chapter 3.2.2 --- Protective role of endotoxin in allergy and asthma development --- p.29
Chapter 3.2.3 --- Deleterious effect of endotoxin exposure in asthma: the dark side --- p.31
Chapter 3.3 --- Allergen --- p.34
Chapter 3.3.1 --- Allergens: an update --- p.34
Chapter 3.3.2 --- Determinants of allergens in home environment --- p.35
Chapter 3.3.3 --- Allergens avoidance: environmental intervention --- p.36
Chapter 3.4 --- Nitrogen dioxide --- p.40
Chapter 3.4.1 --- Determinants of indoor nitrogen dioxide and its relation with gas cooking --- p.40
Chapter 3.4.2 --- The adverse effects of nitrogen dioxide on respiratory symptoms --- p.41
Chapter 3.4.3 --- Reactive nitrogen species and nitrosative stress in asthma --- p.42
Chapter Chapter 4: --- CD14 Single Nucleotide Polymorphisms and Asthma --- p.45
Chapter 4.1 --- Overview of CD14 receptor --- p.45
Chapter 4.2 --- Action of CD14 receptor in endotoxin response --- p.47
Chapter 4.3 --- Relation of CD14 with asthma --- p.48
Chapter 4.3.1 --- Associations between CD14 polymorphisms and asthma phenotypes --- p.48
Chapter 4.3.2 --- Endotoxin switch concept: from gene to gene - environment --- p.52
Chapter Section III: --- Study Core --- p.55
Chapter Chapter 5: --- Methodology in indoor environment investigation and its result --- p.57
Chapter 5.1 --- Study Population --- p.57
Chapter 5.2 --- Home Visiting Protocol --- p.60
Chapter 5.2.1 --- The International Study of Asthma and Allergies in Childhood (ISAAC) --- p.60
Chapter 5.2.2 --- ISAAC questionnaire --- p.61
Chapter 5.2.3 --- House dust collection procedures --- p.62
Chapter 5.2.4 --- Indoor nitrogen dioxide measurements --- p.65
Chapter 5.2.4.1 --- Ogawa passive sampler --- p.65
Chapter 5.2.4.2 --- Preparation and measurement procedures --- p.66
Chapter 5.2.4.3 --- Indoor nitrogen dioxide quantification --- p.67
Chapter 5.3 --- House dust extraction --- p.69
Chapter 5.4 --- House dust endotoxin measurement --- p.70
Chapter 5.5 --- Allergen measurement --- p.72
Chapter 5.6 --- Statistical Analysis --- p.75
Chapter 5.7 --- Results --- p.77
Chapter 5.7.1 --- Demographic data and subjects characteristics --- p.77
Chapter 5.7.2 --- "Dust weight, endotoxin and allergen levels and their determinants in household" --- p.82
Chapter 5.7.3 --- Indoor NO〕2levels and its determinant in household --- p.95
Chapter 5.7.4 --- Associations between indoor environmental factors and respiratory health --- p.96
Chapter 5.7.4.1 --- Clinical symptoms --- p.96
Chapter 5.7.4.2 --- Exhaled NO levels --- p.101
Chapter 5.7.4.3 --- Spirometric indices --- p.103
Chapter Chapter 6： --- Methodology in genotyping CD14 polymorphisms and its result --- p.105
Chapter 6.1 --- Study population --- p.105
Chapter 6.2 --- Serum Total and allergen-specific IgE measurement --- p.106
Chapter 6.3 --- CD14 Genotyping s --- p.107
Chapter 6.3.1 --- Genotyping promoter SNPs ofCD14/-159 and -1359 --- p.107
Chapter 6.3.2 --- Genotyping promoter SNP of CD14/-1619 --- p.109
Chapter 6.3.3 --- Validation of genotyping by sequencing --- p.111
Chapter 6.4 --- Statistical Analysis --- p.112
Chapter 6.5 --- Results --- p.113
Chapter 6.5.1 --- Subjects characteristics and clinical features. --- p.113
Chapter 6.5.2 --- Associations between CD14 SNPs and asthma phenotypes --- p.114
Chapter Chapter 7: --- Discussion --- p.120
Chapter 7.1 --- Influence of indoor factors on asthmatic children --- p.120
Chapter 7.2 --- CD14 polymorphisms in modifying asthma phenotypes --- p.135
Chapter Chapter 8: --- Conclusion and Further Works --- p.138
References --- p.141
Appendix 1 Questionnaire
Appendix 2 Publications
http://library.cuhk.edu.hk/record=b5893253Test
Use of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0Test/)
مصطلحات الفهرس: Asthma in children--Environmental aspects, Asthma in children--Genetic aspects, CD antigens, Genetic polymorphisms, Asthma--physiopathology, Asthma--genetics, Environmental Exposure, Antigens, CD14, Polymorphism, Single Nucleotide, Child, Text, bibliography
URL: https://repository.lib.cuhk.edu.hk/en/item/cuhk-326028Test
الإتاحة: Open access content. Open access content
Use of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0Test/)
ملاحظة: print
xx, 162, [21] leaves : ill. ; 30 cm.
English
Chinese
أرقام أخرى: CVU oai:cuhk-dr:cuhk_326028
cuhk:326028
https://repository.lib.cuhk.edu.hk/en/item/cuhk-326028Test
959216714
المصدر المساهم: CHINESE UNIV OF HONG KONG
From OAIster®, provided by the OCLC Cooperative.
رقم الانضمام: edsoai.ocn959216714
قاعدة البيانات: OAIster
الوصف
الوصف غير متاح.