دورية أكاديمية
Decreased expression of RNA-binding motif protein 3 correlates with tumour progression and poor prognosis in urothelial bladder cancer
| العنوان: | Decreased expression of RNA-binding motif protein 3 correlates with tumour progression and poor prognosis in urothelial bladder cancer |
|---|---|
| المؤلفون: | Boman, Karolina, Segersten, Ulrika, Ahlgren, Göran, Eberhard, Jakob, Uhlén, Mathias, Jirström, Karin, Malmström, Per-Uno |
| بيانات النشر: | Uppsala universitet, Urologkirurgi, 2013. |
| سنة النشر: | 2013 |
| المجموعة: | DiVA Archive at Upsalla University |
| Original Material: | PMID 23565664 ISI:000318004100001 |
| الوصف: | BACKGROUND: Low nuclear expression of the RNA-binding motif protein 3 (RBM3) has previously been found to be associated with poor prognosis in several cancer forms e.g. breast, ovarian, colorectal, prostate cancer and malignant melanoma. The aim of this study was to examine the prognostic impact of RBM3 expression in urinary bladder cancer. METHODS: Immunohistochemical RBM3 expression was examined in tumours from 343 patients with urothelial bladder cancer. Chi-square and Spearman's correlation tests were applied to explore associations between RBM3 expression and clinicopathological characteristics. The impact of RBM3 expression on disease-specific survival (DSS), 5-year overall survival (OS) and progression-free survival (PFS) was assessed by Kaplan-Meier analysis and Cox proportional hazards modelling. RESULTS: Reduced nuclear RBM3 expression was significantly associated with more advanced tumour (T) stage (p |
| Original Identifier: | oai:DiVA.org:uu-199938 |
| نوع الوثيقة: | Article |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | BMC Urology, 1471-2490, 2013, 13, s. 17- |
| DOI: | 10.1186/1471-2490-13-17 |
| الإتاحة: | http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-199938Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsndl.UPSALLA1.oai.DiVA.org.uu.199938 |
| قاعدة البيانات: | Networked Digital Library of Theses & Dissertations |
| DOI: | 10.1186/1471-2490-13-17 |
|---|