رسالة جامعية
Development of metal nanomaterials assists anticoagulant heparin biosensors
| العنوان: | Development of metal nanomaterials assists anticoagulant heparin biosensors |
|---|---|
| العنوان البديل: | 結合金屬奈米材料與抗凝血劑肝素之生化感測器開發與研究 |
| المؤلفون: | Wang, Shuo-Feng, 王碩鋒 |
| مرشدي الرسالة: | Hsieh, You-Zung, 謝有容 |
| سنة النشر: | 2015 |
| المجموعة: | National Digital Library of Theses and Dissertations in Taiwan |
| الوصف: | 103 Heparin could prevent thromboembolism as an anticoagulant drug. However, the excessive heparin doses led to fatal bleeding complication. Therefore, it is important to detect and monitor the concentration of heparin in serum. In this study, two brand new heparin bio-sensors were presented. The core strategy of first heparin electrochemical biosensor was based on specific adsorption between heparin and histamine. Heparin could adsorb on surface of gold nanoparticles, results in significant change of charges on electrode surface. This heparin electrochemical biosensor existed high sensitivity with wide linear range. The other one heparin colorimetric biosensor used lysozyme protected gold nanoclusters (Au NCs) as detection probe. Depending on the specific interaction between heparin and lysozyme, Au NCs aggregated in the presence of heparin, which lost its fluorescence property. By using this heparin colorimetric biosensor, heparin could easily and quickly be analyzed. |
| Original Identifier: | 103NCTU5500085 |
| نوع الوثيقة: | 學位論文 ; thesis |
| وصف الملف: | 49 |
| الإتاحة: | http://ndltd.ncl.edu.tw/handle/q73pv3Test |
| رقم الانضمام: | edsndl.TW.103NCTU5500085 |
| قاعدة البيانات: | Networked Digital Library of Theses & Dissertations |
| الوصف غير متاح. |