رسالة جامعية
The Role of Cigarette Smoke-Derived Carcinogens in Influencing the Antitumor Activity of EGFR Tyrosine Kinase Inhibitors
| العنوان: | The Role of Cigarette Smoke-Derived Carcinogens in Influencing the Antitumor Activity of EGFR Tyrosine Kinase Inhibitors |
|---|---|
| العنوان البديل: | 香菸致癌物質影響表皮生長因子受體酪胺酸激酶抑制劑療效之探討 |
| المؤلفون: | Shu-Lin Wang, 王姝琳 |
| مرشدي الرسالة: | 黃偉謙 |
| سنة النشر: | 2013 |
| المجموعة: | National Digital Library of Theses and Dissertations in Taiwan |
| الوصف: | 102 The risks, leading to high mortality rate of lung cancer all over the world, include smoking, genetic mutation, medical history of lung, and environmental carcinogens, such as asbestos, tar, and coal, and radiation. Overexpression of epidermal growth factor receptor (EGFR) is found in about 40% to 80% of non-small cell lung cancer (NSCLC) patients, and regulates tumor proliferation, apoptosis, and metastasis to promote tumor progression. EGFR tyrosine kinase inhibitors (TKIs), such as gefitinib (IressaR) and erlotinib (TarcevaR), have thereby been used to treat EGFR-overexpressing NSCLC, and their therapeutic efficacy is correlated with the characteristics including East-Asian species, non-smoking history, female, and EGFR mutation. However, it remains undetermined whether and how cigarette smoking affects the therapeutic efficacy of EGFR TKIs. In this study, our data showed that chronic exposure to cigarette smoking extract or tobacco smoke-derived carcinogen benzo[α]pyrene reduced the sensitivity of wild-type EGFR (wtEGFR)-expressing NSCLC cells to EGFR TKIs. Furthermore, these stimulations can activate proto-oncogene MET and switch the oncogenic addition from EGFR to MET, then leading to EGFR TKI-resistance in wtEGFR expressing NSCLC cell lines. These results suggest that combination with MET inhibitors may enhance the therapeutic efficacy of EGFR TKIs in lung cancer patients with smoking history. |
| Original Identifier: | 102CMCH5604008 |
| نوع الوثيقة: | 學位論文 ; thesis |
| وصف الملف: | 57 |
| الإتاحة: | http://ndltd.ncl.edu.tw/handle/cgg3deTest |
| رقم الانضمام: | edsndl.TW.102CMCH5604008 |
| قاعدة البيانات: | Networked Digital Library of Theses & Dissertations |
| الوصف غير متاح. |