Hong, Wooyoung, Feng Liang, Diane Schaak, Marko Loncar, and Qimin Quan. 2014. “Nanoscale Label-free Bioprobes to Detect Intracellular Proteins in Single Living Cells.” Scientific Reports 4 (1): 6179. doi:10.1038/srep06179. http://dx.doi.org/10.1038/srep06179Test.
بيانات النشر:
Nature Publishing Group, 2014.
سنة النشر:
2014
المجموعة:
FAS Scholarly Articles
الوصف:
Fluorescent labeling techniques have been widely used in live cell studies; however, the labeling processes can be laborious and challenging for use in non-transfectable cells, and labels can interfere with protein functions. While label-free biosensors have been realized by nanofabrication, a method to track intracellular protein dynamics in real-time, in situ and in living cells has not been found. Here we present the first demonstration of label-free detection of intracellular p53 protein dynamics through a nanoscale surface plasmon-polariton fiber-tip-probe (FTP).
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