دورية أكاديمية
Orexins/Hypocretins: Gatekeepers of Social Interaction and Motivation
| العنوان: | Orexins/Hypocretins: Gatekeepers of Social Interaction and Motivation |
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| المؤلفون: | Sara Ouaidat, Inês M. Amaral, Diogo G. Monteiro, Hayat Harati, Alex Hofer, Rana El Rawas |
| المصدر: | International Journal of Molecular Sciences, Vol 25, Iss 5, p 2609 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | orexin, hypocretin, social interaction, reward, stress, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Ever since the discovery of the brain’s orexin/hypocretin system, most research was directed toward unveiling its contribution to the normal functioning of individuals. The investigation of reward-seeking behaviors then gained a lot of attention once the distribution of orexinergic neurons was revealed. Here, we discuss findings on the involvement of orexins in social interaction, a natural reward type. While some studies have succeeded in defining the relationship between orexin and social interaction, the controversy regarding its nature (direct or inverse relation) raises questions about what aspects have been overlooked until now. Upon examining the literature, we identified a research gap concerning conditions influencing the impact of orexins on social behavior expression. In this review, we introduce a number of factors (e.g., stress, orexin’s source) that must be considered while studying the role of orexins in social interaction. Furthermore, we refer to published research to investigate the stage at which orexins affect social interaction and we highlight the nucleus accumbens (NAc) shell’s role in social interaction and other rewarding behaviors. Finally, the underlying orexin molecular pathway influencing social motivation in particular illnesses is proposed. We conclude that orexin’s impact on social interaction is multifactorial and depends on specific conditions available at a time. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| العلاقة: | https://www.mdpi.com/1422-0067/25/5/2609Test; https://doaj.org/toc/1661-6596Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms25052609 |
| الوصول الحر: | https://doaj.org/article/daffc485511d43a98de9de5f0790bf1cTest |
| رقم الانضمام: | edsdoj.ffc485511d43a98de9de5f0790bf1c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms25052609 |