دورية أكاديمية
Racial differences in α4β7 expression on CD4+ T cells of HIV-negative men and women who inject drugs.
| العنوان: | Racial differences in α4β7 expression on CD4+ T cells of HIV-negative men and women who inject drugs. |
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| المؤلفون: | Alyssa R Martin, Aida Sivro, Zoe R Packman, Eshan U Patel, Livia R Goes, Lyle R McKinnon, Jacquie Astemborski, Gregory D Kirk, Shruti H Mehta, Claudia Cicala, James Arthos, Andrew D Redd, Thomas C Quinn |
| المصدر: | PLoS ONE, Vol 15, Iss 8, p e0238234 (2020) |
| بيانات النشر: | Public Library of Science (PLoS), 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | IntroductionWe performed a cross-sectional study of HIV-uninfected men and women who inject drugs from the ALIVE cohort to examine if black men and women who inject drugs have higher levels of CD4+ T cells expressing the integrin heterodimer α4β7 compared to white men and women.Materials and methodsFlow cytometry was used to examine expression of α4β7 and other markers associated with different functional CD4+ T cell subsets in both men and women who inject drugs.ResultsHigher levels of α4β7, CCR5, and CCR6 were observed on CD4+ T cells from black participants compared with white participants. In a multivariable model, α4β7 expression differed by race, but not sex, age, or other factors.DiscussionBlack men and women express higher percentages of α4β7 expressing CD4+ T cells, which may play a role in HIV disease. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| العلاقة: | https://doaj.org/toc/1932-6203Test |
| DOI: | 10.1371/journal.pone.0238234 |
| الوصول الحر: | https://doaj.org/article/fe136357cb8b4f28972262775e3fc8ceTest |
| رقم الانضمام: | edsdoj.fe136357cb8b4f28972262775e3fc8ce |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0238234 |