دورية أكاديمية
Loss-of-function variants, non-alcoholic steatohepatitis and adverse liver outcomes: Results from a multi-ethnic Asian cohort
| العنوان: | Loss-of-function variants, non-alcoholic steatohepatitis and adverse liver outcomes: Results from a multi-ethnic Asian cohort |
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| المؤلفون: | Yi-Wen Ting, Amanda Shen-Yee Kong, Shamsul Mohd Zain, Wah-Kheong Chan, Hwa-Li Tan, Zahurin Mohamed, Yuh-Fen Pung, Rosmawati Mohamed |
| المصدر: | Clinical and Molecular Hepatology, Vol 27, Iss 3, Pp 486-498 (2021) |
| بيانات النشر: | Korean Association for the Study of the Liver, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: | polymorphism, genetic, genetic variation, liver diseases, asia, malaysia, Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | Background/Aims 17β-hydroxysteroid dehydrogenase 13 (HSD17B13) variants were recently reported to have significantly lower odds of non-alcoholic fatty liver disease (NAFLD). This is a two-part study that aimed to evaluate the association of HSD17B13 variants with NAFLD and its histological severity, and to identify the association of the variants with clinical outcomes in a cohort of biopsy-proven NAFLD patients. Methods Consecutive biopsy-proven NAFLD patients and controls without fatty liver were recruited for this study between 2009 and 2014. Genotyping for HSD17B13 variants was performed using rhAmp assays. A total of 165 patients with NAFLD were monitored up until August 2019. Clinical outcomes were recorded. Results HSD17B13 rs72613567 TA allele and rs6834314 G allele were associated with lower odds of non-alcoholic steatohepatitis (NASH) in the overall cohort and among ethnic Chinese, but not among ethnic Malays or Indians (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2287-2728 2287-285X |
| العلاقة: | http://e-cmh.org/upload/pdf/cmh-2020-0162.pdfTest; https://doaj.org/toc/2287-2728Test; https://doaj.org/toc/2287-285XTest |
| DOI: | 10.3350/cmh.2020.0162 |
| الوصول الحر: | https://doaj.org/article/fdbd1ed6e2544c85bcf51e6b76980210Test |
| رقم الانضمام: | edsdoj.fdbd1ed6e2544c85bcf51e6b76980210 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22872728 2287285X |
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| DOI: | 10.3350/cmh.2020.0162 |