دورية أكاديمية
Correlation between hepatic human males absent on the first (hMOF) and viral persistence in chronic hepatitis B patients
| العنوان: | Correlation between hepatic human males absent on the first (hMOF) and viral persistence in chronic hepatitis B patients |
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| المؤلفون: | Liwen Chen, Chuanwu Zhu, Fengdi Li, Yun Wang, Rebecca Bao, Zhujun Cao, Xiaogang Xiang, Lei Yan, Lanyi Lin, Gangde Zhao, Qing Xie, Shisan Bao, Hui Wang |
| المصدر: | Cell & Bioscience, Vol 8, Iss 1, Pp 1-8 (2018) |
| بيانات النشر: | BMC, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Biotechnology LCC:Biology (General) LCC:Biochemistry |
| مصطلحات موضوعية: | hMOF, Chronicity, Hepatitis B, Viral replication, Epigenetic regulation, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5, Biochemistry, QD415-436 |
| الوصف: | Abstract Background Chronic hepatitis B (CHB) remains a global health dilemma with high morbidity and mortality. Human males absent on the first (hMOF) (a histone acetyltransferase) is responsible for DNA damage repair, tumorigenesis and cell cycle regulation. Persistence of HBV DNA contributes to cirrhosis and hepatocellular carcinoma (HCC) in CHB patients. Histone acetyltransferase enhances HBV replication, however the precise underlying mechanism of hMOF in HBV replication in CHB patients remains to be explored. This study aims to investigate the correlation between hepatic hMOF and HBV DNA replication in CHB patients, and may provide new insights towards the treatment of CHB patients. Methods hMOF in liver biopsy (CHB, n = 33 HBeAg+; n = 20 HBeAg−, and three healthy controls) was determined, using immunohistochemistry, qPCR and Western blot. The correlation between hMOF and HBsAg, as well as, HBeAg were determined. Results A positive correlation between hMOF and HBV DNA in overall CHB patients was observed. A distinct positive correlation between hMOF and HBsAg and/or HBeAg in HBeAg+ CHB patients was also detected, however not observed between hMOF and HBsAg in HBeAg− CHB patients. No correlation was observed between hMOF and hepatic inflammation severity and fibrotic stage in CHB patients. Conclusions Hepatic hMOF might contribute to host HBV clearance in CHB patients and possible pathogenesis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-3701 |
| العلاقة: | http://link.springer.com/article/10.1186/s13578-018-0215-5Test; https://doaj.org/toc/2045-3701Test |
| DOI: | 10.1186/s13578-018-0215-5 |
| الوصول الحر: | https://doaj.org/article/afce2ec8c8544b868852e7af0c8e2ebbTest |
| رقم الانضمام: | edsdoj.fce2ec8c8544b868852e7af0c8e2ebb |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20453701 |
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| DOI: | 10.1186/s13578-018-0215-5 |