دورية أكاديمية
Genotoxicity of Di (2-ethyl hexyl) phthalate
| العنوان: | Genotoxicity of Di (2-ethyl hexyl) phthalate |
|---|---|
| المؤلفون: | LI Juntao, LI Wenxue, ZHANG Yan, YANG Guangyu, ZHUANG Runxuan, ZHANG Xiaojun, YANG Hui, ZHANG Bo, ZHU Wei, YANG Ying |
| المصدر: | Zhongguo shipin weisheng zazhi, Vol 34, Iss 5, Pp 878-883 (2022) |
| بيانات النشر: | The Editorial Office of Chinese Journal of Food Hygiene, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Food processing and manufacture LCC:Nutrition. Foods and food supply |
| مصطلحات موضوعية: | di（2-ethylhexyl） phthalate, mutagenicity, dna damage, chromosomal aberration, Food processing and manufacture, TP368-456, Nutrition. Foods and food supply, TX341-641 |
| الوصف: | ObjectiveTo assess the genotoxicity of Di（2-ethylhexyl） phthalate （DEHP）.MethodsA series of guideline-compliant assays were performed to evaluate mutagenicity， chromosomal or DNA damage of DEHP， including Ames test， in vitro mammalian chromosome aberration assay and micronucleus test， comet assay， in vivo mice bone marrow micronucleus assay， and spermatogonial chromosomal aberration test.ResultsAmes tests results were negative. In in vitro tests， DEHP did not increase the frequency of chromosomal aberration， micronucleus and DNA break except in the dose of 2.5 and 5.0 mg/mL， which significantly increased the frequency of micronucleus and DNA break. In Vitro mammalian cell micronucleus test was negative. The chromosomal aberration rates in mice spermatogonial cells were 1.6%， 1.4%， 1.8%， 2.4% and 3.8% in negative control， 3.75 (24 h)， 7.5 (24 h)， 15 (24 h) and 15 (48 h) mg/kg·BW of DEHP， respectively. There was an increasing trend without statistical significant between groups.ConclusionDEHP showed no obvious genotoxicity under the test conditions. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Chinese |
| تدمد: | 1004-8456 |
| العلاقة: | http://www.zgspws.com/zgspwszz/article/abstract/202205003?st=article_issueTest; https://doaj.org/toc/1004-8456Test |
| DOI: | 10.13590/j.cjfh.2022.05.003 |
| الوصول الحر: | https://doaj.org/article/fcd5dfb18c3340c0930d72f5907a7be0Test |
| رقم الانضمام: | edsdoj.fcd5dfb18c3340c0930d72f5907a7be0 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 10048456 |
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| DOI: | 10.13590/j.cjfh.2022.05.003 |