دورية أكاديمية
Population-Based COVID-19 Screening in Mexico: Assessment of Symptoms and Their Weighting in Predicting SARS-CoV-2 Infection
| العنوان: | Population-Based COVID-19 Screening in Mexico: Assessment of Symptoms and Their Weighting in Predicting SARS-CoV-2 Infection |
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| المؤلفون: | Margarita L Martinez-Fierro, Martha Diaz-Lozano, Claudia Alvarez-Zuñiga, Leticia A Ramirez-Hernandez, Roxana Araujo-Espino, Perla M Trejo-Ortiz, Fabiana E Mollinedo-Montaño, Yolanda Ortiz-Castro, Sodel Vazquez-Reyes, Perla Velasco-Elizondo, Lidia Garcia-Esquivel, Arturo Araujo-Conejo, Idalia Garza-Veloz |
| المصدر: | Medicina, Vol 57, Iss 4, p 363 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | SARS-CoV-2, COVID-19, symptoms, Medicine (General), R5-920 |
| الوصف: | Background and Objectives: Sentinel surveillance in the early stage of the COVID-19 pandemic in Mexico represented a significant cost reduction and was useful in estimating the population infected with SARS-CoV-2. However, it also implied that many patients were not screened and therefore had no accurate diagnosis. In this study, we carried out a population-based SARS-CoV-2 screening in Mexico to evaluate the COVID-19-related symptoms and their weighting in predicting SARS-CoV-2 infection. We also discuss this data in the context of the operational definition of suspected cases of COVID-19 established by the Mexican Health Authority’s consensus. Materials and Methods: One thousand two hundred seventy-nine subjects were included. They were screened for SARS-CoV-2 using RT-PCR. The weighting of COVID-19 symptoms in predicting SARS-CoV-2 infection was evaluated statistically. Results: Three hundred and twenty-five patients were positive for SARS-CoV-2 and 954 were negative. Fever, asthenia, dysgeusia, and oxygen saturation predicted SARS-CoV-2 infection (odds ratios ranged from 1.74 to 4.98; p < 0.05). The percentage of asymptomatic COVID-19 patients was 36% and only 38.15% met the Mexican operational definition. Cq-values for the gene N of SARS-CoV-2 were significantly higher in asymptomatic subjects than in the groups of COVID-19 patients with neurological, respiratory, and/or musculoskeletal manifestations (p < 0.05). Conclusions: Dysgeusia, fever, and asthenia increased the odds of a positive result for COVID-19 1.74–4.98-fold among the study population. Patients with neurological, respiratory, and/or musculoskeletal manifestations had higher viral loads at COVID-19 diagnosis than those observed in asymptomatic patients. A high percentage of the participants in the study (61.85%) did not meet the operational definition for a suspected case of COVID-19 established by the Mexican Health Authority’s consensus, representing a high percentage of the population that could have remained without a COVID-19 diagnosis, so becoming a potential source of virus spread. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1648-9144 1010-660X |
| العلاقة: | https://www.mdpi.com/1648-9144/57/4/363Test; https://doaj.org/toc/1010-660XTest; https://doaj.org/toc/1648-9144Test |
| DOI: | 10.3390/medicina57040363 |
| الوصول الحر: | https://doaj.org/article/efcae4ed296e4044b2ee864a02700a10Test |
| رقم الانضمام: | edsdoj.fcae4ed296e4044b2ee864a02700a10 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16489144 1010660X |
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| DOI: | 10.3390/medicina57040363 |