دورية أكاديمية
Link between immunoexpression of hMLH1 and hMSH2 proteins and clinical-epidemiological aspects of actinic cheilitis
| العنوان: | Link between immunoexpression of hMLH1 and hMSH2 proteins and clinical-epidemiological aspects of actinic cheilitis |
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| المؤلفون: | Dmitry José de Santana Sarmento, Gustavo Pina Godoy, Márcia Cristina da Costa Miguel, Éricka Janine Dantas da Silveira |
| المصدر: | Anais Brasileiros de Dermatologia, Vol 91, Iss 4, Pp 463-467 (2016) |
| بيانات النشر: | Sociedade Brasileira de Dermatologia, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Dermatology |
| مصطلحات موضوعية: | Cheilitis, Clinical diagnosis, Immunohistochemistry, Dermatology, RL1-803 |
| الوصف: | Abstract: Background: The studies found in the literature associate the immunoexpression of hMLH1 and hMSH2 proteins with histologic aspects, but do not correlate it with clinical and epidemiological data. Objective: To evaluate the immunoexpression of hMLH1 and hMSH2 in actinic cheilitis, correlating it with clinical characteristics. Methods: We analyzed 40 cases. Histological and immunohistochemical analyses were performed. The following clinical variables were evaluated: gender, age range, ethnicity, clinical aspect and occupational sunlight exposure. Statistical evaluation included the Student t-test, while the significance level was set at 5%. Results: Greater immunoexpression of hMLH1 and hMSH2 was observed in females, individuals aged over 40, and mixed-race/black patients. Furthermore, the immunoexpression of these proteins was greater in actinic cheilitis with a white-colored appearance and in patients without occupational sunlight exposure. No statistical differences were observed for the variables studied. Conclusion: This study uncovered variations of hMLH1 and hMSH2 protein expression upon evaluation of clinical aspects in actinic cheilitis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Portuguese |
| تدمد: | 0365-0596 1806-4841 |
| العلاقة: | http://www.scielo.br/pdf/abd/v91n4/0365-0596-abd-91-04-0463.pdfTest; http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016000400463&tlng=enTest; https://doaj.org/toc/0365-0596Test |
| DOI: | 10.1590/abd1806-4841.20164800 |
| الوصول الحر: | https://doaj.org/article/fb7860cfcbae41a5af8fed785a7a1541Test |
| رقم الانضمام: | edsdoj.fb7860cfcbae41a5af8fed785a7a1541 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 03650596 18064841 |
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| DOI: | 10.1590/abd1806-4841.20164800 |