دورية أكاديمية
Tetra-, penta-, and hexa-nor-lanostane triterpenes from the medicinal fungus Ganoderma australe
| العنوان: | Tetra-, penta-, and hexa-nor-lanostane triterpenes from the medicinal fungus Ganoderma australe |
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| المؤلفون: | Lin Zhou, Subiy Akbar, Meng-Xi Wang, He-Ping Chen, Ji-Kai Liu |
| المصدر: | Natural Products and Bioprospecting, Vol 12, Iss 1, Pp 1-10 (2022) |
| بيانات النشر: | SpringerOpen, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Botany |
| مصطلحات موضوعية: | Basidiomycete, Ganoderma australe, Nor-lanostane, Structural determination, Anti-NO production, Botany, QK1-989 |
| الوصف: | Abstract Chemical investigation on the medicinal fungus Ganoderma australe led to the identification of ten new nor-lanostane triterpenes, namely two hexa-nor ones, ganoaustratetraenones A (1) and B (2), five penta-nor ones, ganoaustraldehydes A–E (3–7), and three tetra-nor ones ganoaustrenoic acids A–C (8–10). The chemical structures along with the absolute configurations were determined by extensive spectroscopic analysis of 1D & 2D NMR and HRESIMS data. The postulated biosynthesis pathways of these compounds were proposed. Ganoaustraldehydes A (3) and B (4) showed moderate inhibition against nitric oxide production in RAW264.7 macrophage cells with the respective IC50 values of 32.5, 34.2 µM (the IC50 of positive control pyrrolidine dithiocarbamate was 20.0 µM). Graphical Abstract |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2192-2195 2192-2209 |
| العلاقة: | https://doaj.org/toc/2192-2195Test; https://doaj.org/toc/2192-2209Test |
| DOI: | 10.1007/s13659-022-00356-x |
| الوصول الحر: | https://doaj.org/article/fb13d17f32d947af8dafb79d592e1ee4Test |
| رقم الانضمام: | edsdoj.fb13d17f32d947af8dafb79d592e1ee4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21922195 21922209 |
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| DOI: | 10.1007/s13659-022-00356-x |