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Additive and interaction effects of working memory and motor sequence training on brain functional connectivity

التفاصيل البيبلوغرافية
العنوان: Additive and interaction effects of working memory and motor sequence training on brain functional connectivity
المؤلفون: Priska Zuber, Laura Gaetano, Alessandra Griffa, Manuel Huerbin, Ludovico Pedullà, Laura Bonzano, Anna Altermatt, Charidimos Tsagkas, Katrin Parmar, Patric Hagmann, Jens Wuerfel, Ludwig Kappos, Till Sprenger, Olaf Sporns, Stefano Magon
المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
بيانات النشر: Nature Portfolio, 2021.
سنة النشر: 2021
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Abstract Although shared behavioral and neural mechanisms between working memory (WM) and motor sequence learning (MSL) have been suggested, the additive and interactive effects of training have not been studied. This study aimed at investigating changes in brain functional connectivity (FC) induced by sequential (WM + MSL and MSL + WM) and combined (WM × MSL) training programs. 54 healthy subjects (27 women; mean age: 30.2 ± 8.6 years) allocated to three training groups underwent twenty-four 40-min training sessions over 6 weeks and four cognitive assessments including functional MRI. A double-baseline approach was applied to account for practice effects. Test performances were compared using linear mixed-effects models and t-tests. Resting state fMRI data were analysed using FSL. Processing speed, verbal WM and manual dexterity increased following training in all groups. MSL + WM training led to additive effects in processing speed and verbal WM. Increased FC was found after training in a network including the right angular gyrus, left superior temporal sulcus, right superior parietal gyrus, bilateral middle temporal gyri and left precentral gyrus. No difference in FC was found between double baselines. Results indicate distinct patterns of resting state FC modulation related to sequential and combined WM and MSL training suggesting a relevance of the order of training performance. These observations could provide new insight for the planning of effective training/rehabilitation.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
العلاقة: https://doaj.org/toc/2045-2322Test
DOI: 10.1038/s41598-021-02492-9
الوصول الحر: https://doaj.org/article/acf989ab70b14b12a81ae41a7568a63eTest
رقم الانضمام: edsdoj.f989ab70b14b12a81ae41a7568a63e
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-021-02492-9