دورية أكاديمية
Effect of clofibrate on reducing neonatal jaundice: a systematic review and meta-analysis
| العنوان: | Effect of clofibrate on reducing neonatal jaundice: a systematic review and meta-analysis |
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| المؤلفون: | Fatemeh Eghbalian, Lotfollah Karimi, Roya Raeisi, Ayda Hasanpour Dehkordi, Hamid Bouraghi |
| المصدر: | Osong Public Health and Research Perspectives, Vol 13, Iss 3, Pp 174-183 (2022) |
| بيانات النشر: | Korea Disease Control and Prevention Agency, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Special situations and conditions LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | clofibrate, hyperbilirubinemia, jaundice, neonatal jaundice, Special situations and conditions, RC952-1245, Infectious and parasitic diseases, RC109-216 |
| الوصف: | In neonates, bilirubin tends to be deposited in body tissues, especially the skin and mucous membranes. Jaundice is an early symptom of bilirubin excretion disorders. Therefore, the aim of this study was to investigate the effect of clofibrate on reducing neonatal jaundice. In this systematic review, international databases, including PubMed, Scopus, Web of Science, Embase, Cochrane, and Google Scholar, were searched without time and language restrictions. The reference lists of all studies ultimately included were manually searched. In the 17 articles reviewed, with a sample size of 665 people published between 2005 and 2019, the average weight of the neonates varied from 2,186 g to 4,000 g. Furthermore, the average age of neonates varied from 2 days to 9 days. Four doses of clofibrate (25, 30, 50, 100 mg/kg of neonatal body weight) were used. The bilirubin level of neonates significantly decreased in the intervention group 24, 36, 48, and 72 hours after the start of treatment. Clofibrate administration decreased total serum bilirubin, especially from the second day onwards, and also reduced hospitalization time, hospital costs, and side effects from hospitalization. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2210-9099 2210-9110 |
| العلاقة: | http://ophrp.org/upload/pdf/j-phrp-2021-0336.pdfTest; https://doaj.org/toc/2210-9099Test; https://doaj.org/toc/2210-9110Test |
| DOI: | 10.24171/j.phrp.2021.0336 |
| الوصول الحر: | https://doaj.org/article/f812084e4a3f44678e9e29b675f8504eTest |
| رقم الانضمام: | edsdoj.f812084e4a3f44678e9e29b675f8504e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22109099 22109110 |
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| DOI: | 10.24171/j.phrp.2021.0336 |