التفاصيل البيبلوغرافية
العنوان:
Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases
المؤلفون:
Adriana I. Iglesias , Aniket Mishra , Veronique Vitart , Yelena Bykhovskaya , René Höhn , Henriët Springelkamp , Gabriel Cuellar-Partida , Puya Gharahkhani , Jessica N. Cooke Bailey , Colin E. Willoughby , Xiaohui Li , Seyhan Yazar , Abhishek Nag , Anthony P. Khawaja , Ozren Polašek , David Siscovick , Paul Mitchell , Yih Chung Tham , Jonathan L. Haines , Lisa S. Kearns , Caroline Hayward , Yuan Shi , Elisabeth M. van Leeuwen , Kent D. Taylor , Blue Mountains Eye Study—GWAS group , Pieter Bonnemaijer , Jerome I. Rotter , Nicholas G. Martin , Tanja Zeller , Richard A. Mills , Emmanuelle Souzeau , Sandra E. Staffieri , Jost B. Jonas , Irene Schmidtmann , Thibaud Boutin , Jae H. Kang , Sionne E. M. Lucas , Tien Yin Wong , Manfred E. Beutel , James F. Wilson , NEIGHBORHOOD Consortium , Wellcome Trust Case Control Consortium 2 (WTCCC2) , André G. Uitterlinden , Eranga N. Vithana , Paul J. Foster , Pirro G. Hysi , Alex W. Hewitt , Chiea Chuen Khor , Louis R. Pasquale , Grant W. Montgomery , Caroline C. W. Klaver , Tin Aung , Norbert Pfeiffer , David A. Mackey , Christopher J. Hammond , Ching-Yu Cheng , Jamie E. Craig , Yaron S. Rabinowitz , Janey L. Wiggs , Kathryn P. Burdon , Cornelia M. van Duijn , Stuart MacGregor
المصدر:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
بيانات النشر:
Nature Portfolio, 2018.
سنة النشر:
2018
المجموعة:
LCC:Science
مصطلحات موضوعية:
Science
الوصف:
Reduced central corneal thickness (CCT) is observed in common eye diseases as well as in rare Mendelian disorders. Here, in a cross-ancestry GWAS, the authors identify 19 novel genetic loci associated with CCT, a subset of which is involved in rare corneal or connective tissue disorders.
نوع الوثيقة:
article
وصف الملف:
electronic resource
اللغة:
English
تدمد:
2041-1723
العلاقة:
https://doaj.org/toc/2041-1723Test
DOI:
10.1038/s41467-018-03646-6
الوصول الحر:
https://doaj.org/article/f7334f0a8f8b42b18a3180c2a6650fb9Test
رقم الانضمام:
edsdoj.f7334f0a8f8b42b18a3180c2a6650fb9
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