دورية أكاديمية
Assessing drug target suitability using TargetMine [version 2; peer review: 2 approved]
| العنوان: | Assessing drug target suitability using TargetMine [version 2; peer review: 2 approved] |
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| المؤلفون: | Yi-An Chen, Erika Yogo, Naoko Kurihara, Tomoshige Ohno, Chihiro Higuchi, Masatomo Rokushima, Kenji Mizuguchi |
| المصدر: | F1000Research, Vol 8 (2019) |
| بيانات النشر: | F1000 Research Ltd, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | In selecting drug target candidates for pharmaceutical research, the linkage to disease and the tractability of the target are two important factors that can ultimately determine the drug efficacy. Several existing resources can provide gene-disease associations, but determining whether such a list of genes are attractive drug targets often requires further information gathering and analysis. In addition, few resources provide the information required to evaluate the tractability of a target. To address these issues, we have updated TargetMine, a data warehouse for assisting target prioritization, by integrating new data sources for gene-disease associations and enhancing functionalities for target assessment. As a data mining platform that integrates a variety of data sources, including protein structures and chemical compounds, TargetMine now offers a powerful and flexible interface for constructing queries to check genetic evidence, tractability and other relevant features for the candidate genes. We demonstrate these features by using several specific examples. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2046-1402 |
| العلاقة: | https://f1000research.com/articles/8-233/v2Test; https://doaj.org/toc/2046-1402Test |
| DOI: | 10.12688/f1000research.18214.2 |
| الوصول الحر: | https://doaj.org/article/f618b3fab7cc47e3b9e32110116856e6Test |
| رقم الانضمام: | edsdoj.f618b3fab7cc47e3b9e32110116856e6 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20461402 |
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| DOI: | 10.12688/f1000research.18214.2 |