دورية أكاديمية
DNA methylation entropy as a measure of stem cell replication and aging
| العنوان: | DNA methylation entropy as a measure of stem cell replication and aging |
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| المؤلفون: | Himani Vaidya, Hye Seon Jeong, Kelsey Keith, Shinji Maegawa, Gennaro Calendo, Jozef Madzo, Jaroslav Jelinek, Jean-Pierre J. Issa |
| المصدر: | Genome Biology, Vol 24, Iss 1, Pp 1-18 (2023) |
| بيانات النشر: | BMC, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) LCC:Genetics |
| مصطلحات موضوعية: | DNA methylation, Aging, Stem cell, Cell division, Epigenetic clock, Biology (General), QH301-705.5, Genetics, QH426-470 |
| الوصف: | Abstract Background Epigenetic marks are encoded by DNA methylation and accumulate errors as organisms age. This drift correlates with lifespan, but the biology of how this occurs is still unexplained. We analyze DNA methylation with age in mouse intestinal stem cells and compare them to nonstem cells. Results Age-related changes in DNA methylation are identical in stem and nonstem cells, affect most prominently CpG islands and correlate weakly with gene expression. Age-related DNA methylation entropy, measured by the Jensen-Shannon Distribution, affects up to 25% of the detectable CpG sites and is a better measure of aging than individual CpG methylation. We analyze this entropy as a function of age in seven other tissues (heart, kidney, skeletal muscle, lung, liver, spleen, and blood) and it correlates strikingly with tissue-specific stem cell division rates. Thus, DNA methylation drift and increased entropy with age are primarily caused by and are sensors for, stem cell replication in adult tissues. Conclusions These data have implications for the mechanisms of tissue-specific functional declines with aging and for the development of DNA-methylation-based biological clocks. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1474-760X |
| العلاقة: | https://doaj.org/toc/1474-760XTest |
| DOI: | 10.1186/s13059-023-02866-4 |
| الوصول الحر: | https://doaj.org/article/f5d8cc73b5694855b70f542f7cf5d21cTest |
| رقم الانضمام: | edsdoj.f5d8cc73b5694855b70f542f7cf5d21c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1474760X |
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| DOI: | 10.1186/s13059-023-02866-4 |