دورية أكاديمية
Relationship between microalbuminuria and cardiac structural changes in mild hypertensive patients
| العنوان: | Relationship between microalbuminuria and cardiac structural changes in mild hypertensive patients |
|---|---|
| المؤلفون: | F.L. Plavnik, M.A.M.R.T. Silva, N.E.B. Kohlmann, O. Kohlmann Jr., A.B. Ribeiro, M.T. Zanella |
| المصدر: | Brazilian Journal of Medical and Biological Research, Vol 35, Iss 7, Pp 799-804 (2002) |
| بيانات النشر: | Associação Brasileira de Divulgação Científica, 2002. |
| سنة النشر: | 2002 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Hypertension, Microalbuminuria, Left ventricular hypertrophy, Blood pressure monitoring, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | The aim of this study was to determine the relationship between urinary albumin excretion (UAE), cardiac structural changes upon echocardiography and 24-h ambulatory blood pressure (ABPM) levels. Twenty mild hypertensive patients (mean age 56.8 ± 9.6 years) were evaluated. After 2 weeks of a washout period of all antihypertensive drugs, all patients underwent an echocardiographic evaluation, a 24-h ABPM and an overnight urine collection. Systolic and diastolic blood pressure during 24-h ABPM was 145 ± 14/91 ± 10 mmHg (daytime) and 130 ± 14/76 ± 8 mmHg (nighttime), respectively. Seven (35%) patients presented UAE > or = 15 µg/min, and for the whole group, the geometric mean value for UAE was 10.2 x/÷ 3.86 µg/min. Cardiac measurements showed mean values of interventricular septum thickness (IVS) of 11 ± 2.3 mm, left ventricular posterior wall thickness (PWT) of 10 ± 2.0 mm, left ventricular mass (LVM) of 165 ± 52 g, and left ventricular mass index (LVMI) of 99 ± 31 g/m². A forward stepwise regression model indicated that blood pressure levels did not influence UAE. Significant correlations were observed between UAE and cardiac structural parameters such as IVS (r = 0.71, P or = 15 µg/min for the presence of geometric cardiac abnormalities were 75 and 91.6%. These data indicate that microalbuminuria in essential hypertension represents an early marker of cardiac structural damage. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0100-879X 1414-431X |
| العلاقة: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000700006Test; https://doaj.org/toc/0100-879XTest; https://doaj.org/toc/1414-431XTest |
| DOI: | 10.1590/S0100-879X2002000700006 |
| الوصول الحر: | https://doaj.org/article/f549fd503cc4483eb4d70e501f92c980Test |
| رقم الانضمام: | edsdoj.f549fd503cc4483eb4d70e501f92c980 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 0100879X 1414431X |
|---|---|
| DOI: | 10.1590/S0100-879X2002000700006 |