دورية أكاديمية
Grape seed extract supplement increases bone callus formation and mechanical strength: an animal study
| العنوان: | Grape seed extract supplement increases bone callus formation and mechanical strength: an animal study |
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| المؤلفون: | Murat Gurger, Erhan Yilmaz, Seval Yilmaz, Gokhan Once, Mustafa Konuk, Emre Kaya, Yakup Say, Gokhan Artas, Hakan Artas |
| المصدر: | Journal of Orthopaedic Surgery and Research, Vol 14, Iss 1, Pp 1-10 (2019) |
| بيانات النشر: | BMC, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Orthopedic surgery LCC:Diseases of the musculoskeletal system |
| مصطلحات موضوعية: | Grape seed, Proanthocyanidin, Antioxidant, Fracture healing, Biomechanics, Orthopedic surgery, RD701-811, Diseases of the musculoskeletal system, RC925-935 |
| الوصف: | Abstract Background The positive effects of grape seed proanthocyanidin extract (GSPE) on bone health, which is a potent antioxidant, are known but its effects on fracture healing are not sufficiently covered in the literature. This study aims to investigate the effects of GSPE on fracture healing and biomechanics of healing bone. Materials and methods Sixty-four adult Wistar-Albino male rats were divided into 8 groups of 8 animals in each group. Osteotomy was performed to the right femurs of all groups except the negative control (G1) and positive control (G2) groups, and intramedullary Kirchner wire was used for fixation. GSPE was given to half of the rats (G2-G4-G6-G8) 100 mg/kg/day by oral gavage. The rats were sacrificed on the tenth (G3–G4), twentieth (G5–G6), and thirtieth (G1–G2–G7–G8) days, respectively, and histopathological, radiological, and biomechanical examinations were performed. Results Histopathological examination of the specimens from the callus tissues revealed that bone healing was more prominent in the groups supplemented with GSPE (G4, G6, G8). There was a statistically significant improvement in radiological recovery scores and callus volumes in groups with GSPE. When biomechanical strengths were evaluated, it was found that GSPE increased bone strength not only in fracture groups but also in the positive control group (G2). Conclusions As a result, this study showed that GSPE, a potent anti-oxidant, had a positive effect on bone healing and improved mechanical strength of the healing bone. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1749-799X |
| العلاقة: | http://link.springer.com/article/10.1186/s13018-019-1251-5Test; https://doaj.org/toc/1749-799XTest |
| DOI: | 10.1186/s13018-019-1251-5 |
| الوصول الحر: | https://doaj.org/article/f544a2c625ef42fcb361117b818afef9Test |
| رقم الانضمام: | edsdoj.f544a2c625ef42fcb361117b818afef9 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1749799X |
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| DOI: | 10.1186/s13018-019-1251-5 |