دورية أكاديمية
A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine
| العنوان: | A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine |
|---|---|
| المؤلفون: | G.M. Gimenes, G.O. Santana, M.V.M. Scervino, R. Curi, J.N.B. Pereira |
| المصدر: | Brazilian Journal of Medical and Biological Research, Vol 55 (2022) |
| بيانات النشر: | Associação Brasileira de Divulgação Científica, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Gastrointestinal tract, Type 2 diabetes, GK rats, Intestinal microbiota, Diabetes treatment, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | The Goto-Kakizaki (GK) rat is a non-obese experimental model of type 2 diabetes mellitus (T2DM) that allows researchers to monitor diabetes-induced changes without jeopardizing the effects of obesity. This rat strain exhibits notable gastrointestinal features associated with T2DM, such as marked alterations in intestinal morphology, reduced intestinal motility, slow transit, and modified microbiota compared to Wistar rats. The primary treatments for diabetic patients include administration of hypoglycemic agents and insulin, and lifestyle changes. Emerging procedures, including alternative therapies, metabolic surgeries, and modulation of the intestinal microbiota composition, have been shown to improve the diabetic state of GK rats. This review describes the morpho-physiological diabetic-associated features of the gastrointestinal tract (GIT) of GK rats. We also describe promising strategies, e.g., metabolic surgery and modulation of gut microbiota composition, used to target the GIT of this animal model to improve the diabetic state. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1414-431X 1414-431x |
| العلاقة: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100306&lng=en&tlng=enTest; http://www.scielo.br/pdf/bjmbr/v55/1414-431X-bjmbr-55-e11910.pdfTest; https://doaj.org/toc/1414-431XTest |
| DOI: | 10.1590/1414-431x2022e11910 |
| الوصول الحر: | https://doaj.org/article/dcf3e78aa7f1433cb7c8aa3cd0f3d7ceTest |
| رقم الانضمام: | edsdoj.f3e78aa7f1433cb7c8aa3cd0f3d7ce |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1414431X 1414431x |
|---|---|
| DOI: | 10.1590/1414-431x2022e11910 |