دورية أكاديمية
Prevalence of metastases within the hypothalamic-pituitary area in patients with brain metastases
| العنوان: | Prevalence of metastases within the hypothalamic-pituitary area in patients with brain metastases |
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| المؤلفون: | Stefan Janssen, Preena Mehta, Tobias Bartscht, Sebastian M. Schmid, Fabian B. Fahlbusch, Dirk Rades |
| المصدر: | Radiation Oncology, Vol 14, Iss 1, Pp 1-6 (2019) |
| بيانات النشر: | BMC, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medical physics. Medical radiology. Nuclear medicine LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Brain metastases, Whole brain radiotherapy, Hormonal impairment, Hypothalamus/pituitary gland sparing, QoL, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract Aim To quantify the prevalence of brain metastases involving the hypothalamic-pituitary (HT-P) area. Introduction Cognitive impairment and fatigue are common side effects of whole brain irradiation (WBI) comprising the quality of life (QoL) for survivors. While the former is related to radiation-induced hippocampal injury, the latter could be secondary to hormonal disbalance as a consequence of radiation of the HT-P area. Thus, sparing both regions from higher irradiation doses could reduce these sequelae. Methods T1 contrast medium enhanced magnetic resonance imaging (MRI) scans of 865 patients with brain metastases (4,280 metastases) were reviewed. HT-P area was individually contoured with a margin of 5 mm in order to evaluate the prevalence of brain metastases in this region. Results Involvement of the hypothalamic region was found in 26 patients (involvement rate of 3% for patients and 1% for metastases), involvement of the pituitary gland in 9 patients (1% for patients and 10 brain metastases as the only factor associated with hypothalamic involvement while no distinct factor was associated with an involvement of the pituitary gland. Conclusion The low prevalence of metastases within the HT-P area in patients with brain metastases calls for further studies examining whether sparing of this region might improve patients QoL. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1748-717X |
| العلاقة: | http://link.springer.com/article/10.1186/s13014-019-1337-6Test; https://doaj.org/toc/1748-717XTest |
| DOI: | 10.1186/s13014-019-1337-6 |
| الوصول الحر: | https://doaj.org/article/f3110f56fed54333b6212c07e183bf27Test |
| رقم الانضمام: | edsdoj.f3110f56fed54333b6212c07e183bf27 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1748717X |
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| DOI: | 10.1186/s13014-019-1337-6 |