دورية أكاديمية
Assessment of Genomic Instability in Medical Workers Exposed to Chronic Low-Dose X-Rays in Northern China
| العنوان: | Assessment of Genomic Instability in Medical Workers Exposed to Chronic Low-Dose X-Rays in Northern China |
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| المؤلفون: | Lianying Fang, Jieqing Li, Weiguo Li, Xuesong Mao, Ya Ma, Dianjun Hou, Wei Zhu, Ximing Jia, Jianwei Qiao |
| المصدر: | Dose-Response, Vol 17 (2019) |
| بيانات النشر: | SAGE Publishing, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | Therapeutics. Pharmacology, RM1-950 |
| الوصف: | The increasing use of ionizing radiation (IR) in medical diagnosis and treatment has caused considerable concern regarding the effects of occupational exposure on human health. Despite this concern, little information is available regarding possible effects and the mechanism behind chronic low-dose irradiation. The present study assessed potential genomic damage in workers occupationally exposed to low-dose X-rays. A variety of analyses were conducted, including assessing the level of DNA damage and chromosomal aberrations (CA) as well as cytokinesis-block micronucleus (CBMN) assay, gene expression profiling, and antioxidant level determination. Here, we report that the level of DNA damage, CA, and CBMN were all significantly increased. Moreover, the gene expression and antioxidant activities were changed in the peripheral blood of men exposed to low-dose X-rays. Collectively, our findings indicated a strong correlation between genomic instability and duration of low-dose IR exposure. Our data also revealed the DNA damage repair and antioxidative mechanisms which could result in the observed genomic instability in health-care workers exposed to chronic low-dose IR. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1559-3258 15593258 |
| العلاقة: | https://doaj.org/toc/1559-3258Test |
| DOI: | 10.1177/1559325819891378 |
| الوصول الحر: | https://doaj.org/article/f1a6144c329f4dda92a1950d1329d4c3Test |
| رقم الانضمام: | edsdoj.f1a6144c329f4dda92a1950d1329d4c3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15593258 |
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| DOI: | 10.1177/1559325819891378 |