دورية أكاديمية
Cardioprotective effects of co-administration of thymoquinone and ischemic postconditioning in diabetic rats
| العنوان: | Cardioprotective effects of co-administration of thymoquinone and ischemic postconditioning in diabetic rats |
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| المؤلفون: | Junchuan Ran, Huanglin Xu, Wenyuan Li |
| المصدر: | Iranian Journal of Basic Medical Sciences, Vol 24, Iss 7, Pp 892-899 (2021) |
| بيانات النشر: | Mashhad University of Medical Sciences, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | apoptosis, diabetes, inflammation, ischemic postconditioning, polyphenols, Medicine |
| الوصف: | Objective(s): Ischemia/reperfusion (I/R) is a leading cause of myocardial infarction (MI) injury, contributing to excess injury to cardiac tissues involved in inflammation, apoptosis, and oxidative stress. The present study was conducted to examine the effects of combined thymoquinone (TQ) with ischemic postconditioning (IPostC) therapy on apoptosis and inflammation due to I/R injury in diabetic rat hearts. Materials and Methods: A single dose injection of streptozotocin (STZ; 60 mg/kg) was administered to thirty-two Wistar male rats to induce diabetes. Hearts were fixed on a Langendorff setting and exposed to a 30 min regional ischemia subsequently to 60 min reperfusion. IPostC was induced at the onset of reperfusion by 3 cycles of 30 sec R/I. ELISA, Western blotting assay, and TUNEL staining were applied to assess the cardioprotective effect of IPostC and TQ against I/R injury in diabetic and non-diabetic rats.Results: Administration of TQ alone in non-diabetic isolated hearts significantly diminished CK-MB, TNF-α, IL-1β, and apoptosis and enhanced p-GSK-3β and Bcl-2 (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2008-3866 2008-3874 |
| العلاقة: | https://ijbms.mums.ac.ir/article_18395_5776f1d2a749f8e59c3a909cd9b1319d.pdfTest; https://doaj.org/toc/2008-3866Test; https://doaj.org/toc/2008-3874Test |
| DOI: | 10.22038/ijbms.2021.47670.10981 |
| الوصول الحر: | https://doaj.org/article/f076eef9f6e547e491cb409f2693286cTest |
| رقم الانضمام: | edsdoj.f076eef9f6e547e491cb409f2693286c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20083866 20083874 |
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| DOI: | 10.22038/ijbms.2021.47670.10981 |