دورية أكاديمية
Low Expression of MATR3 Is Associated with Poor Survival in Clear Cell Renal Cell Carcinoma
| العنوان: | Low Expression of MATR3 Is Associated with Poor Survival in Clear Cell Renal Cell Carcinoma |
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| المؤلفون: | Justyna Durślewicz, Anna Klimaszewska-Wiśniewska, Paulina Antosik, Dariusz Grzanka |
| المصدر: | Biomedicines, Vol 11, Iss 2, p 326 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | clear cell renal cell carcinoma, ccRCC, MATR3, prognostic biomarkers, nuclear matrix protein, Biology (General), QH301-705.5 |
| الوصف: | Matrin 3 (MATR3) is one of the most abundant inner nuclear matrix proteins involved in multiple nuclear processes. However, to date, the biological role and prognostic relevance of MATR3 in human cancers still need to be explored. Therefore, the present study aimed to examine the expression levels and prognostic significance of MATR3 in clear cell renal cell carcinoma (ccRCC) patients. We assessed MATR3 immunohistochemical staining and RNA-seq data from publicly available data sets, and the results were analyzed with reference to clinicopathological characteristics and the overall survival of patients. Furthermore, the protein–protein interaction (PPI) network for MATR3 and its neighbors was constructed, functionally annotated, and screened for survival-related genes. MATR3 protein and mRNA levels were lower in tumor tissues compared to control tissues. Lower MATR3 protein (HR 2.36, 95%CI 1.41–3.97; p = 0.001) and mRNA (HR 2.01, 95%CI 1.46–2.75; p < 0.0001) expression levels were found to be a significant independent adverse prognostic factor for the patient’s overall survival (OS). Moreover, of the candidate genes, the MRPL23 gene was identified as being the most predictive of OS, and combined MRPL23/MATR3 expression status predicted patient survival better than looking at each marker individually (HR 3.15, 95%CI 2.05–4.83; p < 0.0001). In conclusion, the results from the present investigation warrant further research into the biological and prognostic value of MATR3 and MRPL23 in ccRCC patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 11020326 2227-9059 |
| العلاقة: | https://www.mdpi.com/2227-9059/11/2/326Test; https://doaj.org/toc/2227-9059Test |
| DOI: | 10.3390/biomedicines11020326 |
| الوصول الحر: | https://doaj.org/article/bf8598b5fc434935b10d172a743fbf97Test |
| رقم الانضمام: | edsdoj.bf8598b5fc434935b10d172a743fbf97 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 11020326 22279059 |
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| DOI: | 10.3390/biomedicines11020326 |