دورية أكاديمية
Reduction of lactoferrin aggravates neuronal ferroptosis after intracerebral hemorrhagic stroke in hyperglycemic mice
| العنوان: | Reduction of lactoferrin aggravates neuronal ferroptosis after intracerebral hemorrhagic stroke in hyperglycemic mice |
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| المؤلفون: | Zhongnan Xiao, Danmin Shen, Ting Lan, Chao Wei, Weihua Wu, Qingyu Sun, Zhaoli Luo, Wen Chen, Yurui Zhang, Liye Hu, Chenguang Zhang, Yamei Wang, Yabin Lu, Peipei Wang, Fei Yang, Qian Li |
| المصدر: | Redox Biology, Vol 50, Iss , Pp 102256- (2022) |
| بيانات النشر: | Elsevier, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Intracerebral hemorrhagic stroke, Hyperglycemia, Ferroptosis, Neutrophil, PPARγ, Lactoferrin, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | Diabetic hyperglycemia aggravates the prognosis of intracerebral hemorrhagic stroke (ICH) in the clinic. In addition to hematoma expansion and increased inflammation, how diabetic hyperglycemia affects the outcomes of ICH is still unclear. We found that streptozotocin-induced diabetic hyperglycemia not only increased neutrophil infiltration, but also changed the gene expression profile of neutrophils, including lactoferrin (Ltf) encoding gene Ltf. Peroxisome proliferator-activated receptor γ (PPARγ) transcribed Ltf and the lack of neutrophilic Ltf transcription and secretion exacerbated neuronal ferroptosis by accumulating intraneuronal iron. Furthermore, the administration of recombinant Ltf protected against neuronal ferroptosis and improved neurobehavior in hyperglycemic ICH mice, and vice versa. These results indicate that supplementing Ltf or inhibiting neuronal ferroptosis are promising potential strategies to improve the acute outcomes of diabetic ICH in the clinic. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2213-2317 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2213231722000283Test; https://doaj.org/toc/2213-2317Test |
| DOI: | 10.1016/j.redox.2022.102256 |
| الوصول الحر: | https://doaj.org/article/be14945240ec40798ee6930af1c11191Test |
| رقم الانضمام: | edsdoj.be14945240ec40798ee6930af1c11191 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22132317 |
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| DOI: | 10.1016/j.redox.2022.102256 |