دورية أكاديمية
Magnetic resonance guided SBRT reirradiation in locally recurrent prostate cancer: a multicentric retrospective analysis
| العنوان: | Magnetic resonance guided SBRT reirradiation in locally recurrent prostate cancer: a multicentric retrospective analysis |
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| المؤلفون: | Luca Boldrini, Angela Romano, Giuditta Chiloiro, Stefanie Corradini, Viola De Luca, Valeria Verusio, Andrea D’Aviero, Alessandra Castelluccia, Anna Rita Alitto, Francesco Catucci, Gianmarco Grimaldi, Christian Trapp, Juliane Hörner-Rieber, Domenico Marchesano, Vincenzo Frascino, Gian Carlo Mattiucci, Vincenzo Valentini, Piercarlo Gentile, Maria Antonietta Gambacorta |
| المصدر: | Radiation Oncology, Vol 18, Iss 1, Pp 1-8 (2023) |
| بيانات النشر: | BMC, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medical physics. Medical radiology. Nuclear medicine LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Prostate cancer, Radiotherapy, Reirradiation, MRgRT, SBRT, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Abstract Aims Reirradiation of prostate cancer (PC) local recurrences represents an emerging challenge for current radiotherapy. In this context, stereotactic body radiation therapy (SBRT) allows the delivery of high doses, with curative intent. Magnetic Resonance guided Radiation Therapy (MRgRT) has shown promising results in terms of safety, feasibility and efficacy of delivering SBRT thanks to the enhanced soft tissue contrast and the online adaptive workflow. This multicentric retrospective analysis evaluates the feasibility and efficacy of PC reirradiation, using a 0.35 T hybrid MR delivery unit. Methods Patients affected by local recurrences of PC and treated in five institutions between 2019 and 2022 were retrospectively collected. All patients had undergone previous Radiation Therapy (RT) in definitive or adjuvant setting. Re-treatment MRgSBRT was delivered with a total dose ranging from 25 to 40 Gy in 5 fractions. Toxicity according to CTCAE v 5.0 and treatment response were assessed at the end of the treatment and at follow-up. Results Eighteen patients were included in this analysis. All patients had previously undergone external beam radiation therapy (EBRT) up to a total dose of 59.36 to 80 Gy. Median cumulative biologically effective dose (BED) of SBRT re-treatment was 213,3 Gy (103,1-560), considering an α/β of 1.5. Complete response was achieved in 4 patients (22.2%). No grade ≥ 2 acute genitourinary (GU) toxicity events were recorded, while gastrointestinal (GI) acute toxicity events occurred in 4 patients (22.2%). Conclusion The low rates of acute toxicity of this experience encourages considering MRgSBRT a feasibile therapeutic approach for the treatment of clinically relapsed PC. Accurate gating of target volumes, the online adaptive planning workflow and the high definition of MRI treatment images allow delivering high doses to the PTV while efficiently sparing organs at risk (OARs). |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1748-717X |
| العلاقة: | https://doaj.org/toc/1748-717XTest |
| DOI: | 10.1186/s13014-023-02271-y |
| الوصول الحر: | https://doaj.org/article/ddbddf09a593464cbabef79e0b1fe07eTest |
| رقم الانضمام: | edsdoj.bddf09a593464cbabef79e0b1fe07e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1748717X |
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| DOI: | 10.1186/s13014-023-02271-y |