دورية أكاديمية
Coupling and Coordination in Gene Expression Processes with Pre-mRNA Splicing
| العنوان: | Coupling and Coordination in Gene Expression Processes with Pre-mRNA Splicing |
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| المؤلفون: | Kewu Pan, Jimmy Tsz Hang Lee, Zhe Huang, Chi-Ming Wong |
| المصدر: | International Journal of Molecular Sciences, Vol 16, Iss 3, Pp 5682-5696 (2015) |
| بيانات النشر: | MDPI AG, 2015. |
| سنة النشر: | 2015 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | pre-mRNA splicing, RNA surveillance, exosome, microRNA processing, mirtron, circular RNA, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | A processing is a tightly regulated and highly complex pathway which includes transcription, splicing, editing, transportation, translation and degradation. It has been well-documented that splicing of RNA polymerase II medicated nascent transcripts occurs co-transcriptionally and is functionally coupled to other RNA processing. Recently, increasing experimental evidence indicated that pre-mRNA splicing influences RNA degradation and vice versa. In this review, we summarized the recent findings demonstrating the coupling of these two processes. In addition, we highlighted the importance of splicing in the production of intronic miRNA and circular RNAs, and hence the discovery of the novel mechanisms in the regulation of gene expression. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 16035682 |
| العلاقة: | http://www.mdpi.com/1422-0067/16/3/5682Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms16035682 |
| الوصول الحر: | https://doaj.org/article/bd428f05a5cd48a0be7871fb80d211a6Test |
| رقم الانضمام: | edsdoj.bd428f05a5cd48a0be7871fb80d211a6 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16035682 |
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| DOI: | 10.3390/ijms16035682 |