دورية أكاديمية
Growth hormone receptor antagonism with pegvisomant in insulin resistant non-diabetic men: A phase II pilot study [version 1; referees: 2 approved]
| العنوان: | Growth hormone receptor antagonism with pegvisomant in insulin resistant non-diabetic men: A phase II pilot study [version 1; referees: 2 approved] |
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| المؤلفون: | Ada P. Lee, Kathleen Mulligan, Morris Schambelan, Elizabeth J. Murphy, Ethan J. Weiss |
| المصدر: | F1000Research, Vol 6 (2017) |
| بيانات النشر: | F1000 Research Ltd, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Diabetes & Obesity, Neuro-Endocrinology & Pituitary, Medicine, Science |
| الوصف: | Background: Growth hormone (GH) is known to affect insulin and glucose metabolism. Blocking its effects in acromegalic patients improves diabetes and glucose metabolism. We aimed to determine the effect of pegvisomant, a GH receptor antagonist, on insulin resistance, endogenous glucose production (EGP) and lipolysis in insulin resistant non-diabetic men. Methods: Four men between the ages of 18-62 with a BMI of 18-35kg/m2, with insulin resistance as defined by a HOMA-IR > 2.77, were treated for four weeks with pegvisomant 20 mg daily. Inpatient metabolic assessments were performed before and after treatment. The main outcome measurements were: change after pegvisomant therapy in insulin sensitivity as measured by hyperinsulinemic euglycemic clamp; and EGP and lipolysis assessed by stable isotope tracer techniques. Results: Insulin like growth factor-1 (IGF-1) concentrations decreased from 134.0 ± 41.5 (mean ± SD) to 72.0 ± 11.7 ng/mL (p = 0.04) after 4 weeks of therapy. Whole body insulin sensitivity index (M/I 3.2 ± 1.3 vs. 3.4 ± 2.4; P = 0.82), as well as suppression of EGP (89.7 ± 26.9 vs. 83.5 ± 21.6%; p = 0.10) and Ra glycerol (59.4 ± 22.1% vs. 61.2 ± 14.4%; p = 0.67) during the clamp were not changed significantly with pegvisomant treatment. Conclusions: Blockade of the GH receptor with pegvisomant for four weeks had no significant effect on insulin/glucose metabolism in a small phase II pilot study of non-diabetic insulin resistant participants without acromegaly. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2046-1402 |
| العلاقة: | https://f1000research.com/articles/6-614/v1Test; https://doaj.org/toc/2046-1402Test |
| DOI: | 10.12688/f1000research.11359.1 |
| الوصول الحر: | https://doaj.org/article/cbcd960441df469cb0b3f9c53f78628fTest |
| رقم الانضمام: | edsdoj.bcd960441df469cb0b3f9c53f78628f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20461402 |
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| DOI: | 10.12688/f1000research.11359.1 |