دورية أكاديمية
Introduction and switching of biologic agents are associated with antidepressant and anxiolytic medication use: data on 42 815 real-world patients with inflammatory rheumatic disease
| العنوان: | Introduction and switching of biologic agents are associated with antidepressant and anxiolytic medication use: data on 42 815 real-world patients with inflammatory rheumatic disease |
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| المؤلفون: | Dimitrios Vassilopoulos, Vasiliki-Kalliopi Bournia, Kalliopi Fragiadaki, Katerina Laskari, Stylianos Panopoulos, Konstantinos Mathioudakis, Anastasios Tsolakidis, Panagiota Mitrou |
| المصدر: | RMD Open, Vol 6, Iss 3 (2020) |
| بيانات النشر: | BMJ Publishing Group, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Medicine |
| الوصف: | Objectives Depression and anxiety are linked bi-directionally with inflammatory rheumatic diseases (IRDs) activity, which in turn, depends on subjective patient reported outcomes that can be distorted by comorbid mood disorders. We tested the hypothesis that introduction and/or switching of biologic agents for IRDs are associated with treatment for depression and/or anxiety, by analysing real-world data.Methods Using a country-wide electronic prescription database (10 012 604 registered, 99% population coverage), we captured almost all patients with rheumatoid arthritis (n=12 002), psoriatic arthritis (n=5465) and ankylosing spondylitis (n=6423) who received biologic disease modifying anti-rheumatic drugs (bDMARDs) during a 2-year period (8/2016–7/2018). Concomitant antidepressant/anxiolytic medication use was documented in patients who started or switched bDMARDs and compared with those who remained on conventional synthetic (cs)DMARDs or the same bDMARD, respectively, by multivariate regression analysis.Results Two-year data analysis on 42 815 patients revealed that bDMARD introduction was associated with both antidepressant [OR: 1.248, 95% CI 1.153 to 1.350, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2020-0013 2056-5933 |
| العلاقة: | https://rmdopen.bmj.com/content/6/3/e001303.fullTest; https://doaj.org/toc/2056-5933Test |
| DOI: | 10.1136/rmdopen-2020-001303 |
| الوصول الحر: | https://doaj.org/article/baacf9c4a9f941478b3a26824ac5b44eTest |
| رقم الانضمام: | edsdoj.baacf9c4a9f941478b3a26824ac5b44e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20200013 20565933 |
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| DOI: | 10.1136/rmdopen-2020-001303 |