دورية أكاديمية
Patterns of Hearing Loss in Irradiated Survivors of Head and Neck Rhabdomyosarcoma
| العنوان: | Patterns of Hearing Loss in Irradiated Survivors of Head and Neck Rhabdomyosarcoma |
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| المؤلفون: | Franciscus A. Diepstraten, Jan Wiersma, Reineke A. Schoot, Rutger R. G. Knops, Charlotte L. Zuur, Annelot J. M. Meijer, Raquel Dávila Fajardo, Bradley R. Pieters, Brian V. Balgobind, Henrike Westerveld, Nicole Freling, Harm van Tinteren, Ludwig E. Smeele, Arjan Bel, Marry M. van den Heuvel-Eibrink, Robert J. Stokroos, Johannes H. M. Merks, Alexander E. Hoetink, Marinka L. F. Hol |
| المصدر: | Cancers, Vol 14, Iss 23, p 5749 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | head and neck rhabdomyosarcoma, radiotherapy, ototoxicity, audiological monitoring, survivorship, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Purpose: The frequency and patterns of HL in a HNRMS survivor cohort were investigated. A dose–effect relationship between the dose to the cochlea and HL was explored. Methods: Dutch survivors treated for HNRMS between 1993 and 2017 with no relapse and at least two years after the end of treatment were eligible for inclusion. The survivors were evaluated for HL with pure-tone audiometry. HL was graded according to the Muenster, Common Terminology Criteria for Adverse Events (CTCAE) v4.03 and International Society for Paediatric Oncology (SIOP) classification. We defined deleterious HL as Muenster ≥ 2b, CTCAE ≥ 2, and SIOP ≥ 2. Mixed-effects logistic regression was used to search for the dose–effect relationship between the irradiation dose to the cochlea and the occurrence of HL. Results: Forty-two HNRMS survivors underwent pure-tone audiometry. The Muenster, CTCAE and SIOP classification showed that 19.0% (n = 8), 14.2% (n = 6) and 11.9% (n = 5) of survivors suffered from HL, respectively. A low-frequency HL pattern with normal hearing or milder hearing loss in the higher frequencies was seen in four survivors. The maximum cochlear irradiation dose was significantly associated with HL (≥Muenster 2b) (p = 0.047). In our series, HL (≥Muenster 2b) was especially observed when the maximum dose to the cochlea exceeded 19 Gy. Conclusion: HL occurred in up to 19% of survivors of HNRMS. More research is needed on HL patterns in HNRMS survivors and on radiotherapy dose–effect relationships. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 14235749 2072-6694 |
| العلاقة: | https://www.mdpi.com/2072-6694/14/23/5749Test; https://doaj.org/toc/2072-6694Test |
| DOI: | 10.3390/cancers14235749 |
| الوصول الحر: | https://doaj.org/article/ba8c9ec2d7f84c919cfc5de8fc9f1337Test |
| رقم الانضمام: | edsdoj.ba8c9ec2d7f84c919cfc5de8fc9f1337 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14235749 20726694 |
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| DOI: | 10.3390/cancers14235749 |