دورية أكاديمية
Vaccination of Diffuse Large B- Cell Lymphoma Patients with Antigen-Primed Dendritic Cells
| العنوان: | Vaccination of Diffuse Large B- Cell Lymphoma Patients with Antigen-Primed Dendritic Cells |
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| المؤلفون: | Masoud Bahrami, Yousef Yousefzadeh, Maryam Ghasemi, Ghasem Janbabaei Mollae, Saeid Abediankenari, Kamran Alimoghaddam |
| المصدر: | Acta Medica Iranica, Vol 51, Iss 5, Pp 284-288 (2013) |
| بيانات النشر: | Tehran University of Medical Sciences, 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | Dendritic cell, Lymphoma, Vaccine, Medicine (General), R5-920 |
| الوصف: | Dendritic cells (DCs) are professional antigen presenting cells that have a potential role in the initiating of immune responses. The cell vaccination is a new strategy in treatment of infectious diseases and cancers. In this study, we have generated monocyte-derived dendritic cells of lymphoma patient's peripheral blood mononuclear cells then; these cells were used as vaccine in lymphoma patients. We generated dendritic cell vaccine from lymphoma patient's blood monocytes with human interleukin-4, granulocyte monocyte colony stimulating factor and then, antigen–primed Dcs were administrated subcutaneously close to the inguinal lymph nodes after maturation of dendritic cells. After 7 days, we analyzed immune response in lymphoma patients with determining of LDH, Beta 2 Microglobulin, CD4+T cell percent, CD8+ Tcell percent and Tumor size before and after vaccination. Furthermore, phenotypic and functional analysis of dendritic cells was performed using anti CD83-FITC monoclonal antibodies. Before vaccination, the mean ± SD of LDH was 530.62±140.65 but after vaccination it was 459±109.45 that significantly different between experimental groups (P=0.002). In addition, the CD8+ T cells percentage significantly different between two groups (P=0.002). We concluded that the use of dendritic cell probably is one of the suitable noninvasive treatments for lymphoma patients that they have not response to chemical drugs |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0044-6025 1735-9694 |
| العلاقة: | http://acta.tums.ac.ir/index.php/acta/article/view/4838/4368Test; https://doaj.org/toc/0044-6025Test; https://doaj.org/toc/1735-9694Test |
| الوصول الحر: | https://doaj.org/article/cba738c8d4c9477a811b07b3289d58a3Test |
| رقم الانضمام: | edsdoj.ba738c8d4c9477a811b07b3289d58a3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 00446025 17359694 |
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