دورية أكاديمية
RMI1 facilitates repair of ionizing radiation–induced DNA damage and maintenance of genomic stability
| العنوان: | RMI1 facilitates repair of ionizing radiation–induced DNA damage and maintenance of genomic stability |
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| المؤلفون: | Lianying Fang, Yuxiao Sun, Mingxin Dong, Mengmeng Yang, Jianxiu Hao, Jiale Li, Huanteng Zhang, Ningning He, Liqing Du, Chang Xu |
| المصدر: | Cell Death Discovery, Vol 9, Iss 1, Pp 1-11 (2023) |
| بيانات النشر: | Nature Publishing Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens LCC:Cytology |
| مصطلحات موضوعية: | Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671 |
| الوصف: | Abstract Ionizing radiation (IR) causes a wide variety of DNA lesions, of which DNA double-stranded breaks (DSBs) are the most deleterious. Homologous recombination (HR) is a crucial route responsible for repairing DSBs. RecQ-mediated genome instability protein 1 (RMI1) is a member of an evolutionarily conserved Bloom syndrome complex, which prevents and resolves aberrant recombination products during HR, thereby promoting genome stability. However, little is known about the role of RMI1 in regulating the cellular response to IR. This study aimed to understand the cellular functions and molecular mechanisms by which RMI1 maintains genomic stability after IR exposure. Here, we showed IR upregulated the RMI1 protein level and induced RMI1 relocation to the DNA damage sites. We also demonstrated that the loss of RMI1 in cells resulted in enhanced levels of DNA damage, sustained cell cycle arrest, and impaired HR repair after IR, leading to reduced cell viability and elevated genome instability. Taken together, our results highlighted the direct roles of RMI1 in response to DNA damage induced by IR and implied that RMI1 might be a new genome safeguard molecule to radiation-induced damage. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2058-7716 |
| العلاقة: | https://doaj.org/toc/2058-7716Test |
| DOI: | 10.1038/s41420-023-01726-1 |
| الوصول الحر: | https://doaj.org/article/b9f7ce952c394d6f9a77a33b28dc6950Test |
| رقم الانضمام: | edsdoj.b9f7ce952c394d6f9a77a33b28dc6950 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20587716 |
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| DOI: | 10.1038/s41420-023-01726-1 |