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Combined copper and zinc deficiency is associated with reduced SARS-CoV-2 immunization response to BNT162b2 vaccination

التفاصيل البيبلوغرافية
العنوان: Combined copper and zinc deficiency is associated with reduced SARS-CoV-2 immunization response to BNT162b2 vaccination
المؤلفون: Thilo Samson Chillon, Kamil Demircan, Julian Hackler, Raban A. Heller, Peyman Kaghazian, Arash Moghaddam, Lutz Schomburg
المصدر: Heliyon, Vol 9, Iss 10, Pp e20919- (2023)
بيانات النشر: Elsevier, 2023.
سنة النشر: 2023
المجموعة: LCC:Science (General)
LCC:Social sciences (General)
مصطلحات موضوعية: Trace elements, Selenium, COVID-19, Ceruloplasmin, Micronutrients, Science (General), Q1-390, Social sciences (General), H1-99
الوصف: The essential trace elements copper, selenium and zinc are of relevance for immunity and immune response to vaccination. In this longitudinal study, adult healthcare workers (n = 126) received two doses of an mRNA vaccine (BNT162b2), and longitudinal serum samples were prepared. Vaccine-induced antibodies and their neutralizing activity were analyzed, and the trace elements copper, zinc, and selenium along with the copper transporter ceruloplasmin were measured. Subjects with combined deficiency of copper and zinc, i.e. both in the lowest tertiles at baseline, displayed particularly low antibody titers at three (Double Q1: 13 AU/mL vs. not double Q1: 29 AU/mL) and six (Double Q1: 200 AU/mL vs. not double Q1: 425 AU/mL) weeks after vaccination (p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2405-8440
العلاقة: http://www.sciencedirect.com/science/article/pii/S2405844023081276Test; https://doaj.org/toc/2405-8440Test
DOI: 10.1016/j.heliyon.2023.e20919
الوصول الحر: https://doaj.org/article/b9f5deabdf8a4500845b62f17ed53442Test
رقم الانضمام: edsdoj.b9f5deabdf8a4500845b62f17ed53442
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:24058440
DOI:10.1016/j.heliyon.2023.e20919