دورية أكاديمية
Capparis spinosa improves the high fat diet-induced non-alcoholic steatohepatitis in rats: the possible role of FGF21
| العنوان: | Capparis spinosa improves the high fat diet-induced non-alcoholic steatohepatitis in rats: the possible role of FGF21 |
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| المؤلفون: | Rasoul Akbari, Hamid Yaghooti, Mohammad Taha Jalali, Laya Sadat Khorsandi, Narges Mohammadtaghvaei |
| المصدر: | BMC Research Notes, Vol 13, Iss 1, Pp 1-7 (2020) |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine LCC:Biology (General) LCC:Science (General) |
| مصطلحات موضوعية: | Capparis spinosa, Liver steatosis, Fibroblast growth factor 21, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390 |
| الوصف: | Abstract Objectives This study focused on the beneficial effects of Capparis spinosa (CS) treatment on the steatohepatitis induced by the administration of a high-fat emulsion in rats. Changes of hepatic expression and secretion of fibroblast growth factor 21 (FGF21) were also evaluated as a probable mechanism of the CS effects on fatty liver. Male Wistar rats were allocated in different groups to receive a normal diet (NC group), a high-fat diet (HF group), or the high-fat emulsion plus CS extract at a dose of 20 mg/kg (HF+CS group). Body and liver weight, liver index, serum biochemical factors, histopathological examination, and serum level and hepatic gene expression of FGF21 were determined. Results CS administration markedly reduced liver weight and index, serum levels of glucose, lipids, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) and improved histological features of nonalcoholic steatohepatitis (NASH) which were induced by HF feeding in this model. CS supplementation also restored the decreased hepatic and serum FGF21 levels in the fatty liver rats. We propose that the FGF21 up-regulation may partly account for the favorable effects of CS in this steatohepatitis model. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1756-0500 |
| العلاقة: | http://link.springer.com/article/10.1186/s13104-020-05200-4Test; https://doaj.org/toc/1756-0500Test |
| DOI: | 10.1186/s13104-020-05200-4 |
| الوصول الحر: | https://doaj.org/article/cb97089e89304c55a4a75aaead7fc0beTest |
| رقم الانضمام: | edsdoj.b97089e89304c55a4a75aaead7fc0be |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 17560500 |
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| DOI: | 10.1186/s13104-020-05200-4 |