دورية أكاديمية
Components of coated vesicles and nuclear pore complexes share a common molecular architecture.
| العنوان: | Components of coated vesicles and nuclear pore complexes share a common molecular architecture. |
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| المؤلفون: | Damien Devos, Svetlana Dokudovskaya, Frank Alber, Rosemary Williams, Brian T Chait, Andrej Sali, Michael P Rout |
| المصدر: | PLoS Biology, Vol 2, Iss 12, p e380 (2004) |
| بيانات النشر: | Public Library of Science (PLoS), 2004. |
| سنة النشر: | 2004 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | Biology (General), QH301-705.5 |
| الوصف: | Numerous features distinguish prokaryotes from eukaryotes, chief among which are the distinctive internal membrane systems of eukaryotic cells. These membrane systems form elaborate compartments and vesicular trafficking pathways, and sequester the chromatin within the nuclear envelope. The nuclear pore complex is the portal that specifically mediates macromolecular trafficking across the nuclear envelope. Although it is generally understood that these internal membrane systems evolved from specialized invaginations of the prokaryotic plasma membrane, it is not clear how the nuclear pore complex could have evolved from organisms with no analogous transport system. Here we use computational and biochemical methods to perform a structural analysis of the seven proteins comprising the yNup84/vNup107-160 subcomplex, a core building block of the nuclear pore complex. Our analysis indicates that all seven proteins contain either a beta-propeller fold, an alpha-solenoid fold, or a distinctive arrangement of both, revealing close similarities between the structures comprising the yNup84/vNup107-160 subcomplex and those comprising the major types of vesicle coating complexes that maintain vesicular trafficking pathways. These similarities suggest a common evolutionary origin for nuclear pore complexes and coated vesicles in an early membrane-curving module that led to the formation of the internal membrane systems in modern eukaryotes. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1544-9173 1545-7885 |
| العلاقة: | https://doaj.org/toc/1544-9173Test; https://doaj.org/toc/1545-7885Test |
| DOI: | 10.1371/journal.pbio.0020380 |
| الوصول الحر: | https://doaj.org/article/b8d5248674d543b188ad4c177bc0a6c0Test |
| رقم الانضمام: | edsdoj.b8d5248674d543b188ad4c177bc0a6c0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15449173 15457885 |
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| DOI: | 10.1371/journal.pbio.0020380 |