دورية أكاديمية
أعرض في EDS

Cytoplasmic NEAT1 Suppresses AML Stem Cell Self‐Renewal and Leukemogenesis through Inactivation of Wnt Signaling

التفاصيل البيبلوغرافية
العنوان: Cytoplasmic NEAT1 Suppresses AML Stem Cell Self‐Renewal and Leukemogenesis through Inactivation of Wnt Signaling
المؤلفون: Huiwen Yan, Zhi Wang, Yao Sun, Liangding Hu, Pengcheng Bu
المصدر: Advanced Science, Vol 8, Iss 22, Pp n/a-n/a (2021)
بيانات النشر: Wiley, 2021.
سنة النشر: 2021
المجموعة: LCC:Science
مصطلحات موضوعية: acute myeloid leukemia, nuclear paraspeckle assembly transcript 1, translocation, ubiquitination, Wnt, Science
الوصف: Abstract As an essential component of paraspeckles, nuclear paraspeckle assembly transcript 1 (NEAT1) localizes in the nucleus, promoting progression of various malignant solid tumors. Herein, an adverse effect of NEAT1 is reported, showing that the short isoform, NEAT1_1 suppresses acute myeloid leukemia (AML) development. NEAT1_1 is downregulated in leukemia stem cells (LSCs) and its decreased expression correlates with recurrence in AML patients. It is demonstrated that NEAT1_1 suppresses leukemogenesis and LSC function but is dispensable for normal hematopoiesis. Mechanistically, NEAT1_1 is released from the nucleus into the cytoplasm of AML cells, regulated by transcription factor C/EBPβ and nuclear protein NAP1L1. Cytoplasmic NEAT1_1 interacts with Wnt component DVL2 and E3 ubiquitin ligase Trim56, facilitates Trim56‐mediated DVL2 degradation, and thus suppresses Wnt signaling. Collectively, the findings show NEAT1_1 is translocated from the nucleus to the cytoplasm and acts as a tumor suppressor in AML.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2198-3844
71855084
العلاقة: https://doaj.org/toc/2198-3844Test
DOI: 10.1002/advs.202100914
الوصول الحر: https://doaj.org/article/b7f2a718550840a79ed60fdfbd44a07eTest
رقم الانضمام: edsdoj.b7f2a718550840a79ed60fdfbd44a07e
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:21983844
71855084
DOI:10.1002/advs.202100914