دورية أكاديمية
Is polycystic ovary syndrome associated with elevated muscle sympathetic nerve activity?
| العنوان: | Is polycystic ovary syndrome associated with elevated muscle sympathetic nerve activity? |
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| المؤلفون: | Alicia Duval, Will Huckins, Danielle E. Berbrier, Charlotte W. Usselman |
| المصدر: | Experimental Physiology, Vol 108, Iss 10, Pp 1250-1256 (2023) |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Physiology |
| مصطلحات موضوعية: | blood pressure, cardiovascular health, muscle sympathetic nerve activity, polycystic ovary syndrome, sympathoexcitation, Physiology, QP1-981 |
| الوصف: | Abstract Polycystic ovary syndrome (PCOS) is a complex disorder characterized by reproductive abnormalities, cardiometabolic disturbances and a heightened risk of cardiovascular disease. A small but compelling body of research demonstrates that females with PCOS present with elevated muscle sympathetic nerve activity (MSNA) at rest. Heightened MSNA is present in lean, overweight and obese females with PCOS, but limited evidence suggests that androgens may be more strongly linked to elevated MSNA in lean females with PCOS than in obese females with PCOS. Although the specific mechanisms underlying elevated MSNA in PCOS remain elusive, sympathetic activation is implicated in the progression of several cardiovascular diseases and may contribute to the cardiovascular pathophysiology of PCOS. Encouragingly, MSNA appears responsive to non‐pharmacological intervention, making the sympathetic nervous system a promising therapeutic target to mitigate cardiovascular risk in PCOS. This brief review summarizes the existing evidence regarding elevated MSNA, cardiovascular risk profile and vascular function, as well as the potential for clinical intervention and future research directions in females with PCOS. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1469-445X 0958-0670 |
| العلاقة: | https://doaj.org/toc/0958-0670Test; https://doaj.org/toc/1469-445XTest |
| DOI: | 10.1113/EP091216 |
| الوصول الحر: | https://doaj.org/article/b7e9f882b1704a15b8d2e13717943ceaTest |
| رقم الانضمام: | edsdoj.b7e9f882b1704a15b8d2e13717943cea |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1469445X 09580670 |
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| DOI: | 10.1113/EP091216 |