دورية أكاديمية
In situ engineered magnesium alloy implant for preventing postsurgical tumor recurrence
| العنوان: | In situ engineered magnesium alloy implant for preventing postsurgical tumor recurrence |
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| المؤلفون: | Wanying Li, Yinghui Wang, Chaojie Che, Xinyu Fu, Yang Liu, Dongzhi Xue, Shuai Zhang, Rui Niu, Hao Zhang, Yue Cao, Shuyan Song, Liren Cheng, Hongjie Zhang |
| المصدر: | Bioactive Materials, Vol 40, Iss , Pp 474-483 (2024) |
| بيانات النشر: | KeAi Communications Co., Ltd., 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Materials of engineering and construction. Mechanics of materials LCC:Biology (General) |
| مصطلحات موضوعية: | Magnesium alloy, Gas therapy, Mild magnetic hyperthermia therapy, Postsurgical tumor recurrence, Materials of engineering and construction. Mechanics of materials, TA401-492, Biology (General), QH301-705.5 |
| الوصف: | Invasive tumors are difficult to be completely resected in clinical surgery due to the lack of clear resection margins, which greatly increases the risk of postoperative recurrence. However, chemotherapy and radiotherapy as the traditional means of postoperative adjuvant therapy, are limited in postoperative applications, such as multi-drug resistance and low sensitivity, etc. Therefore, an engineered magnesium alloy rod is designed as a postoperative implant to completely remove postoperative residual tumor tissue and inhibit tumor recurrence by gas and mild magnetic hyperthermia therapy (MMHT). As a reactive metal, magnesium alloy responds to the acidic tumor microenvironment by continuously generating hydrogen. The in-situ generation of hydrogen not only protects the surrounding normal tissue, but also enables the magnesium alloy to achieve MMHT under low-intensity alternating magnetic field (AMF). Furthermore, the numerous reactive oxygen species (ROS) produced by heat stress will combine with nitric oxide (NO) generated in situ, to produce more toxic reactive nitrogen species (RNS) storm. In summary, engineered magnesium alloy can completely remove residual tumor tissue and inhibit tumor recurrence by MMHT and RNS storm under low-intensity AMF, and the biodegradability of magnesium alloy makes great potential for clinical application. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2452-199X |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2452199X24002160Test; https://doaj.org/toc/2452-199XTest |
| DOI: | 10.1016/j.bioactmat.2024.06.004 |
| الوصول الحر: | https://doaj.org/article/b7449d0daa094941a918c3b8dee3f4b7Test |
| رقم الانضمام: | edsdoj.b7449d0daa094941a918c3b8dee3f4b7 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2452199X |
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| DOI: | 10.1016/j.bioactmat.2024.06.004 |