دورية أكاديمية
A new family of cell surface located purine transporters in Microsporidia and related fungal endoparasites
| العنوان: | A new family of cell surface located purine transporters in Microsporidia and related fungal endoparasites |
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| المؤلفون: | Peter Major, Kacper M Sendra, Paul Dean, Tom A Williams, Andrew K Watson, David T Thwaites, T Martin Embley, Robert P Hirt |
| المصدر: | eLife, Vol 8 (2019) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | Microsporidia, Trachipleistophora hominis, rabbit cell line RK13, Rozellomycota, nucleotide parasitism, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | Plasma membrane-located transport proteins are key adaptations for obligate intracellular Microsporidia parasites, because they can use them to steal host metabolites the parasites need to grow and replicate. However, despite their importance, the functions and substrate specificities of most Microsporidia transporters are unknown. Here, we provide functional data for a family of transporters conserved in all microsporidian genomes and also in the genomes of related endoparasites. The universal retention among otherwise highly reduced genomes indicates an important role for these transporters for intracellular parasites. Using Trachipleistophora hominis, a Microsporidia isolated from an HIV/AIDS patient, as our experimental model, we show that the proteins are ATP and GTP transporters located on the surface of parasites during their intracellular growth and replication. Our work identifies a new route for the acquisition of essential energy and nucleotides for a major group of intracellular parasites that infect most animal species including humans. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| العلاقة: | https://elifesciences.org/articles/47037Test; https://doaj.org/toc/2050-084XTest |
| DOI: | 10.7554/eLife.47037 |
| الوصول الحر: | https://doaj.org/article/b730f6c4470d4df5b8639be2786727dfTest |
| رقم الانضمام: | edsdoj.b730f6c4470d4df5b8639be2786727df |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.47037 |